FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169967013> ?p ?o ?g. }

• W2169967013 endingPage "120" @default.
• W2169967013 startingPage "111" @default.
• W2169967013 abstract "Nitrites and morpholine are ubiquitous environmental contaminants found in drinking water and food. NMOR can be formed endogenously from nitrite and morpholine. Increased levels of reactive oxygen species/ reactive nitrite species (ROS/RNS) are involved in the mechanism of NMOR toxicity. Certain antimicrobial, antifungal and antioxidant potential were observed in heterocyclic benzimidazole derivatives and dimethyl sulfoxide (DMSO). This study was designed to evaluate the biological potential of 3-aminothiazolo[3-2a]benzimadzole-2-carbonitrile in the protection of lung and colon tissues against the increased levels of ROS/RNS that are induced by administration of nitrite and morpholine in drinking water for 15 weeks. Forty adult male rats were categorized into 4 groups, 10 rats each. The results showed a significant increase in NO, lipid peroxidation (LPO), total peroxides (TPO), superoxide anion (O2-) and DNA fragmentation in lung and colon tissues of rats treated with nitrite and morpholine compared to the control group. Moreover, histological observation of the lung and colon tissues showed cell necrosis, increase in the leukocyte infiltration and blood vessel congestion. Immunostaining for inducible nitric oxide synthase (iNOS) showed positive reaction for lung and colon tissues. After the co-treatment of rats with DEMSO and 3-aminothiazolo[3-2a]benzimadzole-2-carbonitrile, all the previous biochemical changes were reduced in addition to the relative improvement in the morphological changes of both lung and colon. In conclusion, the injury in lung and colon tissues induced by nitrite and morpholine may return to the increased production of ROS and to the alterations in the levels of antioxidants. Co-treatment of rats with 3-aminothiazolo[3-2a]benzimadzole-2-carbonitrile and DMSO may protect them against nitrite and morpholine toxicity.   Key words: Nitrite, morpholine, nitrosomorpholine (NMOR), inducible nitric oxide synthase (iNOS), benzimidazole derivatives, dimethyl sulfoxide (DMSO), colon, lung, rat." @default.
• W2169967013 created "2016-06-24" @default.
• W2169967013 creator A5026712286 @default.
• W2169967013 creator A5049742977 @default.
• W2169967013 creator A5066794977 @default.
• W2169967013 creator A5088880091 @default.
• W2169967013 date "2013-07-31" @default.
• W2169967013 modified "2023-10-03" @default.
• W2169967013 title "The protective role of 3-aminothiazolo[3-2a]benzimadzole-2-carbonitrile against lung and colon injury induced by nitrosomorpholine in adult male albino rat" @default.
• W2169967013 cites W114983418 @default.
• W2169967013 cites W129370812 @default.
• W2169967013 cites W1507589487 @default.
• W2169967013 cites W1511302815 @default.
• W2169967013 cites W1566830427 @default.
• W2169967013 cites W1601730250 @default.
• W2169967013 cites W1750690213 @default.
• W2169967013 cites W1775749144 @default.
• W2169967013 cites W1847690989 @default.
• W2169967013 cites W195217094 @default.
• W2169967013 cites W1967603833 @default.
• W2169967013 cites W1968195069 @default.
• W2169967013 cites W1971854671 @default.
• W2169967013 cites W1972780893 @default.
• W2169967013 cites W1977661529 @default.
• W2169967013 cites W1981983251 @default.
• W2169967013 cites W1983310681 @default.
• W2169967013 cites W1983573309 @default.
• W2169967013 cites W1983708215 @default.
• W2169967013 cites W1994016609 @default.
• W2169967013 cites W1998969160 @default.
• W2169967013 cites W1999129336 @default.
• W2169967013 cites W2001040288 @default.
• W2169967013 cites W2007452107 @default.
• W2169967013 cites W2013969094 @default.
• W2169967013 cites W2017110297 @default.
• W2169967013 cites W2019312389 @default.
• W2169967013 cites W2020286598 @default.
• W2169967013 cites W2021100757 @default.
• W2169967013 cites W2021149374 @default.
• W2169967013 cites W2030978466 @default.
• W2169967013 cites W2046219406 @default.
• W2169967013 cites W2059131885 @default.
• W2169967013 cites W2060510783 @default.
• W2169967013 cites W2063444278 @default.
• W2169967013 cites W2073470059 @default.
• W2169967013 cites W2086221449 @default.
• W2169967013 cites W2094751988 @default.
• W2169967013 cites W2098688138 @default.
• W2169967013 cites W2100875858 @default.
• W2169967013 cites W2104984452 @default.
• W2169967013 cites W2114325309 @default.
• W2169967013 cites W2116676973 @default.
• W2169967013 cites W2128245931 @default.
• W2169967013 cites W2141160571 @default.
• W2169967013 cites W2141819645 @default.
• W2169967013 cites W2145661531 @default.
• W2169967013 cites W2147908356 @default.
• W2169967013 cites W2147993424 @default.
• W2169967013 cites W2152535492 @default.
• W2169967013 cites W2168434682 @default.
• W2169967013 cites W2266929960 @default.
• W2169967013 cites W2949704214 @default.
• W2169967013 cites W433088743 @default.
• W2169967013 doi "https://doi.org/10.5897/jtehs12.011" @default.
• W2169967013 hasPublicationYear "2013" @default.
• W2169967013 type Work @default.
• W2169967013 sameAs 2169967013 @default.
• W2169967013 citedByCount "0" @default.
• W2169967013 crossrefType "journal-article" @default.
• W2169967013 hasAuthorship W2169967013A5026712286 @default.
• W2169967013 hasAuthorship W2169967013A5049742977 @default.
• W2169967013 hasAuthorship W2169967013A5066794977 @default.
• W2169967013 hasAuthorship W2169967013A5088880091 @default.
• W2169967013 hasBestOaLocation W21699670131 @default.
• W2169967013 hasConcept C126322002 @default.
• W2169967013 hasConcept C155647269 @default.
• W2169967013 hasConcept C178790620 @default.
• W2169967013 hasConcept C185592680 @default.
• W2169967013 hasConcept C2776179834 @default.
• W2169967013 hasConcept C2776384668 @default.
• W2169967013 hasConcept C2777622882 @default.
• W2169967013 hasConcept C2777714996 @default.
• W2169967013 hasConcept C2778004101 @default.
• W2169967013 hasConcept C2779525624 @default.
• W2169967013 hasConcept C2780829032 @default.
• W2169967013 hasConcept C2781056017 @default.
• W2169967013 hasConcept C48349386 @default.
• W2169967013 hasConcept C519581460 @default.
• W2169967013 hasConcept C55493867 @default.
• W2169967013 hasConcept C71924100 @default.
• W2169967013 hasConcept C98274493 @default.
• W2169967013 hasConceptScore W2169967013C126322002 @default.
• W2169967013 hasConceptScore W2169967013C155647269 @default.
• W2169967013 hasConceptScore W2169967013C178790620 @default.
• W2169967013 hasConceptScore W2169967013C185592680 @default.
• W2169967013 hasConceptScore W2169967013C2776179834 @default.
• W2169967013 hasConceptScore W2169967013C2776384668 @default.
• W2169967013 hasConceptScore W2169967013C2777622882 @default.

• next