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• W2169969151 abstract "To explore the interactions between regulatory T cells and pathogenic effector cytokines, we have developed a model of a T cell-mediated systemic autoimmune disorder resembling graft-versus-host disease. The cytokine responsible for tissue inflammation in this disorder is interleukin (IL)-17, whereas interferon (IFN)-gamma produced by Th1 cells has a protective effect in this setting. Because of the interest in potential therapeutic approaches utilizing transfer of regulatory T cells and inhibition of the IL-2 pathway, we have explored the roles of these in the systemic disease. We demonstrate that the production of IL-17 and tissue infiltration by IL-17-producing cells occur and are even enhanced in the absence of IL-2. Regulatory T cells favor IL-17 production but prevent the disease when administered early in the course by suppressing expansion of T cells. Thus, the pathogenic or protective effects of cytokines and the therapeutic capacity of regulatory T cells are crucially dependent on the timing and the nature of the disease." @default.
• W2169969151 created "2016-06-24" @default.
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• W2169969151 date "2006-11-27" @default.
• W2169969151 modified "2023-10-17" @default.
• W2169969151 title "Role of IL-17 and regulatory T lymphocytes in a systemic autoimmune disease" @default.
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• W2169969151 doi "https://doi.org/10.1084/jem.20061341" @default.
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