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• W2170001322 abstract "The study was to investigate the effects of combinations of ochratoxin A (OTA) and T-2 toxin on immune function of yellow-feathered broiler chickens. Three-hundred sixty 21-d-old broiler chickens were randomly assigned to 3 groups, each group consisting of 4 duplicates each with 30 chickens. The 3 groups were fed the following diets for 3 wk: C, basal diet (control, mycotoxin-free); L, basal diet + 0.25 mg/kg of OTA, 0.5 mg/kg of T-2 toxin; and H, basal diet + 0.5 mg/kg of OTA, 1 mg/kg of T-2 toxin. Body weight and feed consumption of chickens in the H group decreased significantly (P < 0.05) during the study, but their efficiency of feed utilization was not affected. The feeding of OTA-T-2 toxin diets decreased not only the relative weight of spleen, thymus, and bursa of Fabricius, but also serum concentrations of total protein, albumin, and globulin. Meanwhile, the feeding of OTA-T-2 toxin diets elevated the activities of serum γ-glutamyltransferase, asparate aminotransferase, and alanine aminotransferase. The results of methyl thiazolyl tetrazolium reduction assay indicated that the mitogenic responses of peripheral blood lymphocytes were diminished significantly (P < 0.05 for L group; P < 0.01 for H group). Flow cytometry was employed to determine 3 indexes in peripheral blood lymphocyte of broilers, including CD4+/CD3+, CD8+/CD3+, and CD4+/CD8+. Both toxin treatments significantly decreased (P < 0.01) CD4+/CD3+ and CD4+/CD8+ ratios. In summary, the combination of OTA and T-2 toxin impaired chick immune function even at combined concentrations as low as 0.25 mg/kg of OTA and 0.5 mg/kg of T-2 toxin." @default.
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• W2170001322 date "2009-03-01" @default.
• W2170001322 modified "2023-09-24" @default.
• W2170001322 title "Effects of combinations of ochratoxin A and T-2 toxin on immune function of yellow-feathered broiler chickens" @default.
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• W2170001322 doi "https://doi.org/10.3382/ps.2008-00329" @default.
• W2170001322 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19211518" @default.
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