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- W2170043142 abstract "Esophagogastric resection and anastomosis have long served as a technically demanding task for gastrointestinal and thoracic surgeons. The location of the structures involved and the morbidity incurred from ischemia of the completed conduit have put into question the validity of the operation. Several techniques including preoperative embolization of specified vessels, vascular anastomoses at the time of esophagogastric anastomosis, and staged vascular ligation followed by delayed esophagogastric resection and anastomosis have been employed over the last 50 years to reduce leak rates from 25% to less than 6% in some series. Angiogenic gene therapy is now being investigated as a modality to further reduce morbidity of the anastomosis. The next advancement in esophagogastric resection and anastomosis will likely utilize a multidisciplinary approach with endoscopic delivery of conditioning agents, as well as surgical preparation of the conduit in order to reduce morbidity and optimize patient outcomes." @default.
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- W2170043142 date "2009-05-05" @default.
- W2170043142 modified "2023-09-30" @default.
- W2170043142 title "The Esophageal Anastomosis: How Improving Blood Supply Affects Leak Rate" @default.
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- W2170043142 doi "https://doi.org/10.1007/s11605-009-0906-7" @default.
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