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• W2170059940 abstract "The term ‘‘oxidative stress” refers to a cell’s state characterized by excessive production of reactive oxygen species (ROS) and oxidative stress is one of the most important regulatory mechanisms for stem, cancer, and cancer stem cells. The concept of cancer stem cells arose from observations of similarities between the self-renewal mechanism of stem cells and that of cancer stem cells, but compared to normal stem cells, they are believed to have no control over the cell number. ROS have been implicated in diverse processes in various cancers, and generally the increase of ROS in cancer cells is known to play an important role in the initiation and progression of cancer. Additionally, ROS have been considered as the most significant mutagens in stem cells; when elevated, blocking self-renewal and at the same time, serving as a signal stimulating stem cell differentiation. Several signaling pathways enhanced by oxidative stress are suggested to have important roles in tumorigenesis of cancer or cancer stem cells and the self-renewal ability of stem or cancer stem cells. It is now well established that mitochondria play a prominent role in apoptosis and increasing evidence supports that apoptosis and autophagy are physiological phenomena closely linked with oxidative stress. This review elucidates the effect and the mechanism of the oxidative stress on the regulation of stem, cancer, and cancer stem cells and focuses on the cell signaling cascades stimulated by oxidative stress and their mechanism in cancer stem cell formation, as very little is known about the redox status in cancer stem cells. Moreover, we explain the link between ROS and both of apoptosis and autophagy and the impact on cancer development and treatment. Better understanding of this intricate link may shed light on mechanisms that lead to better modes of cancer treatment." @default.
• W2170059940 created "2016-06-24" @default.
• W2170059940 creator A5005365021 @default.
• W2170059940 creator A5022409275 @default.
• W2170059940 creator A5024361810 @default.
• W2170059940 creator A5056262620 @default.
• W2170059940 date "2010-05-17" @default.
• W2170059940 modified "2023-09-27" @default.
• W2170059940 title "Role of Oxidative Stress in Stem, Cancer, and Cancer Stem Cells" @default.
• W2170059940 cites W1500827124 @default.
• W2170059940 cites W1521025961 @default.
• W2170059940 cites W1577403013 @default.
• W2170059940 cites W1937991665 @default.
• W2170059940 cites W1945827446 @default.
• W2170059940 cites W1963621555 @default.
• W2170059940 cites W1966091165 @default.
• W2170059940 cites W1967085696 @default.
• W2170059940 cites W1967423388 @default.
• W2170059940 cites W1969033749 @default.
• W2170059940 cites W1970160229 @default.
• W2170059940 cites W1976385326 @default.
• W2170059940 cites W1981868559 @default.
• W2170059940 cites W1982647833 @default.
• W2170059940 cites W1984825308 @default.
• W2170059940 cites W1984943603 @default.
• W2170059940 cites W1984948591 @default.
• W2170059940 cites W1985339653 @default.
• W2170059940 cites W1985553251 @default.
• W2170059940 cites W1986857654 @default.
• W2170059940 cites W1990845261 @default.
• W2170059940 cites W1991962444 @default.
• W2170059940 cites W1992676863 @default.
• W2170059940 cites W1993240075 @default.
• W2170059940 cites W1994318934 @default.
• W2170059940 cites W1995888220 @default.
• W2170059940 cites W1997280228 @default.
• W2170059940 cites W1999356404 @default.
• W2170059940 cites W2000605323 @default.
• W2170059940 cites W2004861601 @default.
• W2170059940 cites W2008608024 @default.
• W2170059940 cites W2009143053 @default.
• W2170059940 cites W2009187135 @default.
• W2170059940 cites W2009886857 @default.
• W2170059940 cites W2013485244 @default.
• W2170059940 cites W2013705864 @default.
• W2170059940 cites W2016040396 @default.
• W2170059940 cites W2017457264 @default.
• W2170059940 cites W2017855147 @default.
• W2170059940 cites W2018053695 @default.
• W2170059940 cites W2018765068 @default.
• W2170059940 cites W2019047723 @default.
• W2170059940 cites W2020827871 @default.
• W2170059940 cites W2021050536 @default.
• W2170059940 cites W2021149374 @default.
• W2170059940 cites W2022297771 @default.
• W2170059940 cites W2023427658 @default.
• W2170059940 cites W2024497944 @default.
• W2170059940 cites W2024520801 @default.
• W2170059940 cites W2025128734 @default.
• W2170059940 cites W2028298372 @default.
• W2170059940 cites W2028735479 @default.
• W2170059940 cites W2029073164 @default.
• W2170059940 cites W2029231546 @default.
• W2170059940 cites W2031035635 @default.
• W2170059940 cites W2031770999 @default.
• W2170059940 cites W2032096654 @default.
• W2170059940 cites W2032930928 @default.
• W2170059940 cites W2033040828 @default.
• W2170059940 cites W2035880310 @default.
• W2170059940 cites W2039388529 @default.
• W2170059940 cites W2039640335 @default.
• W2170059940 cites W2041056262 @default.
• W2170059940 cites W2041749024 @default.
• W2170059940 cites W2041897873 @default.
• W2170059940 cites W2042041984 @default.
• W2170059940 cites W2046577989 @default.
• W2170059940 cites W2047860183 @default.
• W2170059940 cites W2048553024 @default.
• W2170059940 cites W2049708884 @default.
• W2170059940 cites W2051197187 @default.
• W2170059940 cites W2052830369 @default.
• W2170059940 cites W2054618296 @default.
• W2170059940 cites W2057403210 @default.
• W2170059940 cites W2059586921 @default.
• W2170059940 cites W2060551076 @default.
• W2170059940 cites W2061728585 @default.
• W2170059940 cites W2062654253 @default.
• W2170059940 cites W2063403801 @default.
• W2170059940 cites W2063478423 @default.
• W2170059940 cites W2074152898 @default.
• W2170059940 cites W2075505804 @default.
• W2170059940 cites W2076775496 @default.
• W2170059940 cites W2079356804 @default.
• W2170059940 cites W2080816163 @default.
• W2170059940 cites W2085872402 @default.
• W2170059940 cites W2092015913 @default.
• W2170059940 cites W2092534289 @default.
• W2170059940 cites W2094040645 @default.

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