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• W2170061845 endingPage "1065" @default.
• W2170061845 startingPage "1055" @default.
• W2170061845 abstract "Adrenocortical carcinoma (ACC) is a rare and typically aggressive malignancy. Available recommendations are based primarily on retrospective series or expert opinions, and only few prospective clinical studies have yet been published. To combine the available evidence for diagnostic work-up and treatment of ACC to a contemporary recommendation on the management of this disease. We conducted a systematic literature search for studies conducted on humans and published in English using the Medline/PubMed database up to 31 January 2011. In addition, we screened published abstracts at meetings and several Web sites for recommendations on ACC management. In patients with suspected localised ACC, a thorough endocrine and imaging work-up is followed by complete (R0) resection of the tumour by an expert surgeon. In experienced hands, laparoscopic adrenalectomy is probably as effective and safe for localised and noninvasive ACC as open surgery. Most clinicians agree that mitotane should be used as adjuvant therapy in the majority of patients, as they have a high risk for recurrence. An international panel has suggested using tumour stage, resection status, and the proliferation marker Ki67 as guidance for or against adjuvant therapy. In patients with advanced disease at presentation or recurrence not amenable to complete resection, a surgical approach is frequently inadequate. In these cases, mitotane alone or in combination with cytotoxic drugs is the treatment of choice. The most promising regimens (etoposide, doxorubicin, cisplatin plus mitotane, and streptozotocin plus mitotane) are currently compared in an international phase 3 trial, and results should be available by the end of 2011. Several targeted therapies are under investigation and may lead to new treatment options. Management of endocrine manifestations with steroidogenesis inhibitors is required in patients suffering uncontrolled hormone excess. Detailed recommendations are provided to guide the management of patients with ACC." @default.
• W2170061845 created "2016-06-24" @default.
• W2170061845 creator A5016606339 @default.
• W2170061845 creator A5053470808 @default.
• W2170061845 creator A5083745890 @default.
• W2170061845 date "2011-11-01" @default.
• W2170061845 modified "2023-09-30" @default.
• W2170061845 title "Contemporary Management of Adrenocortical Carcinoma" @default.
• W2170061845 cites W1498201240 @default.
• W2170061845 cites W192367042 @default.
• W2170061845 cites W1964953687 @default.
• W2170061845 cites W19658340 @default.
• W2170061845 cites W1966402276 @default.
• W2170061845 cites W1966536771 @default.
• W2170061845 cites W1968963856 @default.
• W2170061845 cites W1977852698 @default.
• W2170061845 cites W1978219906 @default.
• W2170061845 cites W1980615409 @default.
• W2170061845 cites W1983781771 @default.
• W2170061845 cites W1983998217 @default.
• W2170061845 cites W1988623266 @default.
• W2170061845 cites W1988688032 @default.
• W2170061845 cites W1989008858 @default.
• W2170061845 cites W1989850686 @default.
• W2170061845 cites W1990996907 @default.
• W2170061845 cites W1991690093 @default.
• W2170061845 cites W1993559104 @default.
• W2170061845 cites W1994325777 @default.
• W2170061845 cites W1995422284 @default.
• W2170061845 cites W1995488361 @default.
• W2170061845 cites W1998151123 @default.
• W2170061845 cites W2003278673 @default.
• W2170061845 cites W2003721774 @default.
• W2170061845 cites W2008345499 @default.
• W2170061845 cites W2010872613 @default.
• W2170061845 cites W2012899953 @default.
• W2170061845 cites W2014131190 @default.
• W2170061845 cites W2015107399 @default.
• W2170061845 cites W2015159206 @default.
• W2170061845 cites W2016982939 @default.
• W2170061845 cites W2023370041 @default.
• W2170061845 cites W2027230133 @default.
• W2170061845 cites W2031590233 @default.
• W2170061845 cites W2032845851 @default.
• W2170061845 cites W2034570079 @default.
• W2170061845 cites W2035178765 @default.
• W2170061845 cites W2039836243 @default.
• W2170061845 cites W2040642687 @default.
• W2170061845 cites W2043083431 @default.
• W2170061845 cites W2044368873 @default.
• W2170061845 cites W2045466543 @default.
• W2170061845 cites W2046152713 @default.
• W2170061845 cites W2050111607 @default.
• W2170061845 cites W2052570942 @default.
• W2170061845 cites W2056135857 @default.
• W2170061845 cites W2060868546 @default.
• W2170061845 cites W2063410286 @default.
• W2170061845 cites W2068845486 @default.
• W2170061845 cites W2073541423 @default.
• W2170061845 cites W2074531404 @default.
• W2170061845 cites W2075373951 @default.
• W2170061845 cites W2079874148 @default.
• W2170061845 cites W2080838501 @default.
• W2170061845 cites W2084654797 @default.
• W2170061845 cites W2089304791 @default.
• W2170061845 cites W2089817687 @default.
• W2170061845 cites W2093713748 @default.
• W2170061845 cites W2095699011 @default.
• W2170061845 cites W2096051245 @default.
• W2170061845 cites W2096859456 @default.
• W2170061845 cites W2097666366 @default.
• W2170061845 cites W2099915083 @default.
• W2170061845 cites W2102885350 @default.
• W2170061845 cites W2104149388 @default.
• W2170061845 cites W2105635119 @default.
• W2170061845 cites W2107287100 @default.
• W2170061845 cites W2107313549 @default.
• W2170061845 cites W2114075665 @default.
• W2170061845 cites W2114210346 @default.
• W2170061845 cites W2114699004 @default.
• W2170061845 cites W2114819486 @default.
• W2170061845 cites W2117360867 @default.
• W2170061845 cites W2117631910 @default.
• W2170061845 cites W2118227907 @default.
• W2170061845 cites W2120191373 @default.
• W2170061845 cites W2120477753 @default.
• W2170061845 cites W2126489403 @default.
• W2170061845 cites W2127472396 @default.
• W2170061845 cites W2130937309 @default.
• W2170061845 cites W2138512324 @default.
• W2170061845 cites W2138551378 @default.
• W2170061845 cites W2140991656 @default.
• W2170061845 cites W2142530545 @default.
• W2170061845 cites W2145168501 @default.
• W2170061845 cites W2145531386 @default.
• W2170061845 cites W2146827226 @default.
• W2170061845 cites W2148626383 @default.
• W2170061845 cites W2153694652 @default.

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