Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170071103> ?p ?o ?g. }
- W2170071103 endingPage "R62" @default.
- W2170071103 startingPage "R49" @default.
- W2170071103 abstract "Glucocorticoids (GCs) are broadly prescribed for numerous pathological conditions because of their anti-inflammatory, antiallergic and immunosuppressive effects, among other actions. Nevertheless, GCs can produce undesired diabetogenic side effects through interactions with the regulation of glucose homeostasis. Under conditions of excess and/or long-term treatment, GCs can induce peripheral insulin resistance (IR) by impairing insulin signalling, which results in reduced glucose disposal and augmented endogenous glucose production. In addition, GCs can promote abdominal obesity, elevate plasma fatty acids and triglycerides, and suppress osteocalcin synthesis in bone tissue. In response to GC-induced peripheral IR and in an attempt to maintain normoglycaemia, pancreatic β-cells undergo several morphofunctional adaptations that result in hyperinsulinaemia. Failure of β-cells to compensate for this situation favours glucose homeostasis disruption, which can result in hyperglycaemia, particularly in susceptible individuals. GC treatment does not only alter pancreatic β-cell function but also affect them by their actions that can lead to hyperglucagonaemia, further contributing to glucose homeostasis imbalance and hyperglycaemia. In addition, the release of other islet hormones, such as somatostatin, amylin and ghrelin, is also affected by GC administration. These undesired GC actions merit further consideration for the design of improved GC therapies without diabetogenic effects. In summary, in this review, we consider the implication of GC treatment on peripheral IR, islet function and glucose homeostasis." @default.
- W2170071103 created "2016-06-24" @default.
- W2170071103 creator A5037297701 @default.
- W2170071103 creator A5048567884 @default.
- W2170071103 creator A5073458837 @default.
- W2170071103 creator A5091100404 @default.
- W2170071103 date "2014-09-30" @default.
- W2170071103 modified "2023-10-13" @default.
- W2170071103 title "Glucocorticoid treatment and endocrine pancreas function: implications for glucose homeostasis, insulin resistance and diabetes" @default.
- W2170071103 cites W1599884739 @default.
- W2170071103 cites W1835200336 @default.
- W2170071103 cites W1920345562 @default.
- W2170071103 cites W1937194455 @default.
- W2170071103 cites W1954125531 @default.
- W2170071103 cites W1959874853 @default.
- W2170071103 cites W1964102466 @default.
- W2170071103 cites W1968419823 @default.
- W2170071103 cites W1968709787 @default.
- W2170071103 cites W1969834886 @default.
- W2170071103 cites W1973562485 @default.
- W2170071103 cites W1974022347 @default.
- W2170071103 cites W1979139803 @default.
- W2170071103 cites W1980676792 @default.
- W2170071103 cites W1980740451 @default.
- W2170071103 cites W1983709201 @default.
- W2170071103 cites W1986112645 @default.
- W2170071103 cites W1986519087 @default.
- W2170071103 cites W1987354827 @default.
- W2170071103 cites W1987555746 @default.
- W2170071103 cites W1988096315 @default.
- W2170071103 cites W1988365339 @default.
- W2170071103 cites W1990714106 @default.
- W2170071103 cites W1991178295 @default.
- W2170071103 cites W1991448709 @default.
- W2170071103 cites W1992470138 @default.
- W2170071103 cites W1994088876 @default.
- W2170071103 cites W1995061101 @default.
- W2170071103 cites W1997042349 @default.
- W2170071103 cites W1997103341 @default.
- W2170071103 cites W1998594551 @default.
- W2170071103 cites W2002598831 @default.
- W2170071103 cites W2009837365 @default.
- W2170071103 cites W2011986858 @default.
- W2170071103 cites W2014093079 @default.
- W2170071103 cites W2019567818 @default.
- W2170071103 cites W2020716369 @default.
- W2170071103 cites W2023656506 @default.
- W2170071103 cites W2026253713 @default.
- W2170071103 cites W2032125948 @default.
- W2170071103 cites W2038148790 @default.
- W2170071103 cites W2039556928 @default.
- W2170071103 cites W2047135359 @default.
- W2170071103 cites W2047680032 @default.
- W2170071103 cites W2047761422 @default.
- W2170071103 cites W2049857957 @default.
- W2170071103 cites W2051391060 @default.
- W2170071103 cites W2054115898 @default.
- W2170071103 cites W2067181732 @default.
- W2170071103 cites W2068107832 @default.
- W2170071103 cites W2073246777 @default.
- W2170071103 cites W2074973168 @default.
- W2170071103 cites W2077012846 @default.
- W2170071103 cites W2078881833 @default.
- W2170071103 cites W2080855259 @default.
- W2170071103 cites W2086656047 @default.
- W2170071103 cites W2089363568 @default.
- W2170071103 cites W2092235287 @default.
- W2170071103 cites W2093022889 @default.
- W2170071103 cites W2097259690 @default.
- W2170071103 cites W2097543219 @default.
- W2170071103 cites W2098957321 @default.
- W2170071103 cites W2099866582 @default.
- W2170071103 cites W2100132478 @default.
- W2170071103 cites W2104572166 @default.
- W2170071103 cites W2106798564 @default.
- W2170071103 cites W2107958082 @default.
- W2170071103 cites W2110172023 @default.
- W2170071103 cites W2111218950 @default.
- W2170071103 cites W2119186903 @default.
- W2170071103 cites W2119513121 @default.
- W2170071103 cites W2122271489 @default.
- W2170071103 cites W2123255057 @default.
- W2170071103 cites W2124159257 @default.
- W2170071103 cites W2130517208 @default.
- W2170071103 cites W2132626407 @default.
- W2170071103 cites W2134658745 @default.
- W2170071103 cites W2135491929 @default.
- W2170071103 cites W2137027678 @default.
- W2170071103 cites W2137921442 @default.
- W2170071103 cites W2142464121 @default.
- W2170071103 cites W2144285392 @default.
- W2170071103 cites W2155100338 @default.
- W2170071103 cites W2155772175 @default.
- W2170071103 cites W2156180953 @default.
- W2170071103 cites W2156884698 @default.
- W2170071103 cites W2160065587 @default.
- W2170071103 cites W2162165724 @default.
- W2170071103 cites W2167226873 @default.