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- W2170085655 endingPage "767" @default.
- W2170085655 startingPage "735" @default.
- W2170085655 abstract "N-methyl-d-aspartate (NMDA) receptor antagonists have therapeutic potential in numerous CNS disorders ranging from acute neurodegeneration (e.g. stroke and trauma), chronic neurodegeneration (e.g. Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, ALS) to symptomatic treatment (e.g. epilepsy, Parkinson’s disease, drug dependence, depression, anxiety and chronic pain). However, many NMDA receptor antagonists also produce highly undesirable side effects at doses within their putative therapeutic range. This has unfortunately led to the conclusion that NMDA receptor antagonism is not a valid therapeutic approach. However, memantine is clearly an uncompetitive NMDA receptor antagonist at therapeutic concentrations achieved in the treatment of dementia and is essentially devoid of such side effects at doses within the therapeutic range. This has been attributed to memantine’s moderate potency and associated rapid, strongly voltage-dependent blocking kinetics. The aim of this review is to summarise preclinical data on memantine supporting its mechanism of action and promising profile in animal models of chronic neurodegenerative diseases. The ultimate purpose is to provide evidence that it is indeed possible to develop clinically well tolerated NMDA receptor antagonists, a fact reflected in the recent interest of several pharmaceutical companies in developing compounds with similar properties to memantine." @default.
- W2170085655 created "2016-06-24" @default.
- W2170085655 creator A5003380923 @default.
- W2170085655 creator A5060706996 @default.
- W2170085655 creator A5071702581 @default.
- W2170085655 date "1999-06-01" @default.
- W2170085655 modified "2023-10-05" @default.
- W2170085655 title "Memantine is a clinically well tolerated N-methyl-d-aspartate (NMDA) receptor antagonist—a review of preclinical data" @default.
- W2170085655 cites W1481764224 @default.
- W2170085655 cites W1552342156 @default.
- W2170085655 cites W1556569805 @default.
- W2170085655 cites W1589136255 @default.
- W2170085655 cites W1600539804 @default.
- W2170085655 cites W1603224320 @default.
- W2170085655 cites W1614954929 @default.
- W2170085655 cites W1904871314 @default.
- W2170085655 cites W1932992301 @default.
- W2170085655 cites W1939552157 @default.
- W2170085655 cites W1964341679 @default.
- W2170085655 cites W1965175806 @default.
- W2170085655 cites W1965204194 @default.
- W2170085655 cites W1965870634 @default.
- W2170085655 cites W1966245721 @default.
- W2170085655 cites W1967335449 @default.
- W2170085655 cites W1968395650 @default.
- W2170085655 cites W1968840823 @default.
- W2170085655 cites W1969087751 @default.
- W2170085655 cites W1969161817 @default.
- W2170085655 cites W1969804029 @default.
- W2170085655 cites W1970268864 @default.
- W2170085655 cites W1970616575 @default.
- W2170085655 cites W1970882462 @default.
- W2170085655 cites W1971110150 @default.
- W2170085655 cites W1971235436 @default.
- W2170085655 cites W1972989088 @default.
- W2170085655 cites W1973047320 @default.
- W2170085655 cites W1973117505 @default.
- W2170085655 cites W1973354999 @default.
- W2170085655 cites W1973558008 @default.
- W2170085655 cites W1974054529 @default.
- W2170085655 cites W1974269419 @default.
- W2170085655 cites W1974574229 @default.
- W2170085655 cites W1974609764 @default.
- W2170085655 cites W1976250238 @default.
- W2170085655 cites W1977472501 @default.
- W2170085655 cites W1978171643 @default.
- W2170085655 cites W1978192104 @default.
- W2170085655 cites W1978287624 @default.
- W2170085655 cites W1978376339 @default.
- W2170085655 cites W1979016938 @default.
- W2170085655 cites W1979106397 @default.
- W2170085655 cites W1980340730 @default.
- W2170085655 cites W1981462008 @default.
- W2170085655 cites W1983473217 @default.
- W2170085655 cites W1985757207 @default.
- W2170085655 cites W1986017124 @default.
- W2170085655 cites W1987387780 @default.
- W2170085655 cites W1988321110 @default.
- W2170085655 cites W1988353352 @default.
- W2170085655 cites W1988799569 @default.
- W2170085655 cites W1988836643 @default.
- W2170085655 cites W1989726412 @default.
- W2170085655 cites W1990560606 @default.
- W2170085655 cites W1993749473 @default.
- W2170085655 cites W1993850362 @default.
- W2170085655 cites W1994109837 @default.
- W2170085655 cites W1994997357 @default.
- W2170085655 cites W1995211181 @default.
- W2170085655 cites W1995535776 @default.
- W2170085655 cites W1995803391 @default.
- W2170085655 cites W1997098970 @default.
- W2170085655 cites W1997568797 @default.
- W2170085655 cites W1998672670 @default.
- W2170085655 cites W1999244829 @default.
- W2170085655 cites W1999429685 @default.
- W2170085655 cites W2000127186 @default.
- W2170085655 cites W2000484187 @default.
- W2170085655 cites W2000749207 @default.
- W2170085655 cites W2002920317 @default.
- W2170085655 cites W2003059369 @default.
- W2170085655 cites W2003066583 @default.
- W2170085655 cites W2003439867 @default.
- W2170085655 cites W2003756518 @default.
- W2170085655 cites W2005245689 @default.
- W2170085655 cites W2006018333 @default.
- W2170085655 cites W2007004955 @default.
- W2170085655 cites W2008054932 @default.
- W2170085655 cites W2009560451 @default.
- W2170085655 cites W2011035664 @default.
- W2170085655 cites W2011066824 @default.
- W2170085655 cites W2011149655 @default.
- W2170085655 cites W2012064273 @default.
- W2170085655 cites W2012586761 @default.
- W2170085655 cites W2013079163 @default.
- W2170085655 cites W2013820308 @default.
- W2170085655 cites W2013868610 @default.
- W2170085655 cites W2013970546 @default.
- W2170085655 cites W2014218809 @default.