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• W2170085729 abstract "Previous research has demonstrated that functional connectivity (FC) among nodes in distributed brain networks is reduced in aging and neurodegenerative disease, based on resting-state functional MRI (rs-fMRI). However, there are few investigations of heterogeneity among network connections in terms of their peak strength in young adulthood, the time course of reductions with age, and relationships with brain structure. We collected structural MRI and rs-fMRI data from 40 young adults (mean age 25.4 ± 2.5) and 76 elders (mean age 74.3 ± 6.8). We calculated global gray matter (GM) volumes, white matter hyperintensity (WMH) volumes, and fractional anisotropy (FA norm, a measure of white matter integrity) from T1 € weighted, FLAIR, and diffusion tensor MRI. fMRI image preprocessing and FC analyses identified a set of functionally inter-correlated regions traditionally referred to as the default mode network (DMN): posterior cingulate (PCC), medial prefrontal (MPF), and right and left inferior parietal (RIP, LIP) cortices. FC values for 6 pairwise connections among these regions were calculated and Z transformed. To explore the magnitude of connectivity reductions with age, we normalized each elderly FC (FC norm) by dividing by corresponding average young FC. We then used principal components analysis (PCA) to analyze patterns of covariance among the pairwise connectivity reduction values among elders. FC among distinct node pairs was heterogeneous in the young, but was substantially reduced in all 6 connections among elders (Table; all p's<0.001), with MPF-PCC connections showing the greatest reduction (43% of young mean on average). PCA suggested that the set of 6 pairwise connectivities was well explained by a single principal component representing global, coordinated reductions to all 6 connections. Within elders, associations between FC norm and age, GM, and WMH were not significant; however greater global FA norm was associated with lesser MPF-PCC (P = 0.009) and MPF-RIP (P = 0.04) FC norm. In healthy aging, functional connectivity among all pairs of DMN nodes may reduce in a coordinated fashion from heterogeneous peak young adult values. These connectivity reductions do not co-occur with brain structural changes in a straightforward or linear way. It is critical to understand the biological basis of age-related network connectivity reductions, which may reflect diverse biological processes of brain aging." @default.
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• W2170085729 date "2012-07-01" @default.
• W2170085729 modified "2023-10-16" @default.
• W2170085729 title "IC-P-127: Heterogeneity of functional connectivity reductions in normal cognitive aging" @default.
• W2170085729 doi "https://doi.org/10.1016/j.jalz.2012.05.161" @default.
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