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• W2170092510 abstract "As a potent inducing agent for IgE production and differentiation factor for allergen-specific Th2 cells, IL-4 is a key regulatory cytokine both in the pathogenesis of allergic disease and in the ongoing allergic response. The assay of In vitro IL-4 production has often been used to compare the allergen responses of T cells Isolated from atopic and non-atopic subjects. Because peripheral blood basophils also have the capacity to respond to specific allergen by producing IL-4, we investigated the relative contribution of these two cell types to IL-4 production in allergen-stimulated primary cultures. Among unfractionated peripheral blood mononuclear cells (PBMC), the major producers of detectable IL-4 In primary In vitro cultures were found to be basophils based on: (i) an allergen dose-response corresponding closely to that required for basophll histamlne release and lower than that required for T cell activation; (II) a rapid time course for IL-4 production (detectable at 3 h), Inconsistent with the typical activation requirements of fresh T cells; (iii) the production of comparable levels of IL-4 In cultures stimulated with allergen or anti-lgE; and (Iv) the complete loss of detectable IL-4 production following specific depletion of basophils from PBMC. The T cells In these cultures were functionally able to produce IL-4, as demonstrated by mitogen activation of basophll-depleted PBMC. These findings demonstrate that although IL-4 production In primary In vitro cultures can be used as a sensitive Indicator of allergen responsiveness, the accurate Interpretation of this result requires Identification of the responding cell type. Furthermore, these findings raise the possibility that basophll production of IL-4 early in the course of allergen stimulation may shape subsequent T cell responses both In vivo and In vitro." @default.
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• W2170092510 date "1996-01-01" @default.
• W2170092510 modified "2023-09-26" @default.
• W2170092510 title "IL-4 production by allergen-stimulated primary cultures: identification of basophils as the major IL-4-producing cell type" @default.
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• W2170092510 doi "https://doi.org/10.1093/intimm/8.8.1287" @default.
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