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- W2170096200 abstract "Metabolic flexibility is the capacity of a system to adjust fuel (primarily glucose and fatty acids) oxidation based on nutrient availability. The ability to alter substrate oxidation in response to nutritional state depends on the genetically influenced balance between oxidation and storage capacities. Competition between fatty acids and glucose for oxidation occurs at the level of the pyruvate dehydrogenase complex (PDC). The PDC is normally active in most tissues in the fed state, and suppressing PDC activity by pyruvate dehydrogenase (PDH) kinase (PDK) is crucial to maintain energy homeostasis under some extreme nutritional conditions in mammals. Conversely, inappropriate suppression of PDC activity might promote the development of metabolic diseases. This review summarizes PDKs’ pivotal role in control of metabolic flexibility under various nutrient conditions and in different tissues, with emphasis on the best characterized PDK4. Understanding the regulation of PDC and PDKs and their roles in energy homeostasis could be beneficial to alleviate metabolic inflexibility and to provide possible therapies for metabolic diseases, including type 2 diabetes (T2D)." @default.
- W2170096200 created "2016-06-24" @default.
- W2170096200 creator A5007322337 @default.
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- W2170096200 creator A5030059975 @default.
- W2170096200 creator A5077744463 @default.
- W2170096200 creator A5083856821 @default.
- W2170096200 date "2014-02-12" @default.
- W2170096200 modified "2023-10-17" @default.
- W2170096200 title "The pivotal role of pyruvate dehydrogenase kinases in metabolic flexibility" @default.
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- W2170096200 doi "https://doi.org/10.1186/1743-7075-11-10" @default.
- W2170096200 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3925357" @default.
- W2170096200 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24520982" @default.
- W2170096200 hasPublicationYear "2014" @default.
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