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- W2170097211 abstract "The effect of endogenous interleukin-12 (IL-12) on the influenza virus immune response in BALB/c mice was evaluated. Following primary influenza virus infection, IL-12 mRNA and protein are detected in the lung, with live virus being required for cytokine induction. Endogenous IL-12 contributes to early NK cell-dependent gamma interferon (IFN-gamma) production (days 3 and 5) but not late T-cell-dependent IFN-gamma secretion (day 7). IL-12 contributes to the inhibition of early virus replication but is not required for virus clearance. IL-12 also modestly contributes to the activation of cytotoxic T lymphocytes. Thus, in this model of experimental influenza virus infection, endogenous IL-12 contributes primarily to the early development and activation of the innate immune response." @default.
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- W2170097211 date "1998-06-01" @default.
- W2170097211 modified "2023-10-14" @default.
- W2170097211 title "Role of Interleukin-12 in Primary Influenza Virus Infection" @default.
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- W2170097211 doi "https://doi.org/10.1128/jvi.72.6.4825-4831.1998" @default.
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