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- W2170107603 endingPage "a000216" @default.
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- W2170107603 abstract "NF-kappaB refers to multiple dimers of Rel homology domain (RHD) containing polypeptides, which are controlled by a stimulus-responsive signaling system that mediates the physiological responses to inflammatory intercellular cytokines, pathogen exposure, and developmental signals. The NF-kappaB signaling system operates on transient or short timescales, relevant to inflammation and immune responses, and on longer-term timescales relevant to cell differentiation and organ formation. Here, we summarize our current understanding of the kinetic mechanisms that allow for NF-kappaB regulation at these different timescales. We distinguish between the regulation of NF-kappaB dimer formation and the regulation of NF-kappaB activity. Given the number of regulators and reactions involved, the NF-kappaB signaling system is capable of integrating a multitude of signals to tune NF-kappaB activity, signal dose responsiveness, and dynamic control. We discuss the prevailing mechanisms that mediate signaling cross talk." @default.
- W2170107603 created "2016-06-24" @default.
- W2170107603 creator A5047177237 @default.
- W2170107603 creator A5079875633 @default.
- W2170107603 date "2009-10-07" @default.
- W2170107603 modified "2023-10-18" @default.
- W2170107603 title "The Regulatory Logic of the NF- B Signaling System" @default.
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- W2170107603 doi "https://doi.org/10.1101/cshperspect.a000216" @default.
- W2170107603 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2827908" @default.
- W2170107603 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20182598" @default.
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