FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170110588> ?p ?o ?g. }

• W2170110588 abstract "Combretastatin A-4 (CA-4), which is an excellent antineoplastic agent, was isolated from Combretum caffrum. To date, structural modification studies of CA-4 have focused predominantly on the construction of new therapeutic agents for drug discovery. As a part of our ongoing work towards the modification of natural products, we have focused on the 3'-O-substituent groups in the B-ring of CA-4 under the hypothesis that these novel derivatives will possess good bioactivities and behave as effective antiproliferative pro-drugs.A series of novel CA-4 derivatives, which contained a 3'-O-substituted carbonic ether moiety, were synthesized and evaluated for their antitumor activities against four tumor cell lines, including MDA-MB-231, MCF-7, K562 and A549 cells. These derivatives exhibited clear antitumor activities, and CA-4E, in particular, showed the highest bioactivity of all of the derivatives tested against all four tumor cell lines, with IC50 values in the range of 1 to 180 nM. Based on its high bioactivity, CA-4E was subsequently selected to investigate the antitumor mechanism of these synthetic compounds. The cell cycle results demonstrated that CA-4E induced time- and dose-dependent G2/M arrest in a similar manner to CA-4, although its effect was more powerful than that of CA-4, and the apoptosis data showed that CA-4E induced cellular apoptosis in a dose-dependent manner.The newly synthesized CA-4 derivatives exhibited good antitumor activities in vitro, with CA-4E, in particular, showing the highest bioactivity of all of the compounds tested. Furthermore, CA-4E induced time- and dose-dependent G2/M arrest and cellular apoptosis in a dose-dependent manner. Taken together, these results suggest that CA-4E should be subjected to further investigation as a potential anticancer drug candidate." @default.
• W2170110588 created "2016-06-24" @default.
• W2170110588 creator A5020872682 @default.
• W2170110588 creator A5029674464 @default.
• W2170110588 creator A5037283558 @default.
• W2170110588 creator A5063850857 @default.
• W2170110588 date "2013-12-01" @default.
• W2170110588 modified "2023-09-22" @default.
• W2170110588 title "Synthesis and biological evaluation of Combretastatin A-4 derivatives containing a 3’-O-substituted carbonic ether moiety as potential antitumor agents" @default.
• W2170110588 cites W1964672215 @default.
• W2170110588 cites W1967392210 @default.
• W2170110588 cites W1968539484 @default.
• W2170110588 cites W1976246404 @default.
• W2170110588 cites W1985036211 @default.
• W2170110588 cites W1988131122 @default.
• W2170110588 cites W1994297035 @default.
• W2170110588 cites W2006273356 @default.
• W2170110588 cites W2007687296 @default.
• W2170110588 cites W2031195720 @default.
• W2170110588 cites W2032549673 @default.
• W2170110588 cites W2035513212 @default.
• W2170110588 cites W2040197644 @default.
• W2170110588 cites W2053023561 @default.
• W2170110588 cites W2071902341 @default.
• W2170110588 cites W2075099861 @default.
• W2170110588 cites W2088228460 @default.
• W2170110588 cites W2128186312 @default.
• W2170110588 cites W2172504993 @default.
• W2170110588 cites W271840341 @default.
• W2170110588 doi "https://doi.org/10.1186/1752-153x-7-179" @default.
• W2170110588 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3878987" @default.
• W2170110588 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24304592" @default.
• W2170110588 hasPublicationYear "2013" @default.
• W2170110588 type Work @default.
• W2170110588 sameAs 2170110588 @default.
• W2170110588 citedByCount "23" @default.
• W2170110588 countsByYear W21701105882015 @default.
• W2170110588 countsByYear W21701105882016 @default.
• W2170110588 countsByYear W21701105882017 @default.
• W2170110588 countsByYear W21701105882018 @default.
• W2170110588 countsByYear W21701105882020 @default.
• W2170110588 countsByYear W21701105882021 @default.
• W2170110588 countsByYear W21701105882022 @default.
• W2170110588 countsByYear W21701105882023 @default.
• W2170110588 crossrefType "journal-article" @default.
• W2170110588 hasAuthorship W2170110588A5020872682 @default.
• W2170110588 hasAuthorship W2170110588A5029674464 @default.
• W2170110588 hasAuthorship W2170110588A5037283558 @default.
• W2170110588 hasAuthorship W2170110588A5063850857 @default.
• W2170110588 hasBestOaLocation W21701105881 @default.
• W2170110588 hasConcept C105696609 @default.
• W2170110588 hasConcept C178790620 @default.
• W2170110588 hasConcept C185592680 @default.
• W2170110588 hasConcept C190283241 @default.
• W2170110588 hasConcept C202751555 @default.
• W2170110588 hasConcept C20418707 @default.
• W2170110588 hasConcept C21951064 @default.
• W2170110588 hasConcept C2776568683 @default.
• W2170110588 hasConcept C2778275628 @default.
• W2170110588 hasConcept C2778689049 @default.
• W2170110588 hasConcept C2780407432 @default.
• W2170110588 hasConcept C29537977 @default.
• W2170110588 hasConcept C55493867 @default.
• W2170110588 hasConcept C71240020 @default.
• W2170110588 hasConcept C84425145 @default.
• W2170110588 hasConcept C86803240 @default.
• W2170110588 hasConcept C95444343 @default.
• W2170110588 hasConceptScore W2170110588C105696609 @default.
• W2170110588 hasConceptScore W2170110588C178790620 @default.
• W2170110588 hasConceptScore W2170110588C185592680 @default.
• W2170110588 hasConceptScore W2170110588C190283241 @default.
• W2170110588 hasConceptScore W2170110588C202751555 @default.
• W2170110588 hasConceptScore W2170110588C20418707 @default.
• W2170110588 hasConceptScore W2170110588C21951064 @default.
• W2170110588 hasConceptScore W2170110588C2776568683 @default.
• W2170110588 hasConceptScore W2170110588C2778275628 @default.
• W2170110588 hasConceptScore W2170110588C2778689049 @default.
• W2170110588 hasConceptScore W2170110588C2780407432 @default.
• W2170110588 hasConceptScore W2170110588C29537977 @default.
• W2170110588 hasConceptScore W2170110588C55493867 @default.
• W2170110588 hasConceptScore W2170110588C71240020 @default.
• W2170110588 hasConceptScore W2170110588C84425145 @default.
• W2170110588 hasConceptScore W2170110588C86803240 @default.
• W2170110588 hasConceptScore W2170110588C95444343 @default.
• W2170110588 hasIssue "1" @default.
• W2170110588 hasLocation W21701105881 @default.
• W2170110588 hasLocation W21701105882 @default.
• W2170110588 hasLocation W21701105883 @default.
• W2170110588 hasLocation W21701105884 @default.
• W2170110588 hasOpenAccess W2170110588 @default.
• W2170110588 hasPrimaryLocation W21701105881 @default.
• W2170110588 hasRelatedWork W2059609559 @default.
• W2170110588 hasRelatedWork W2105586224 @default.
• W2170110588 hasRelatedWork W2114293009 @default.
• W2170110588 hasRelatedWork W2128093567 @default.
• W2170110588 hasRelatedWork W2517799130 @default.
• W2170110588 hasRelatedWork W2591662518 @default.
• W2170110588 hasRelatedWork W2917233431 @default.
• W2170110588 hasRelatedWork W2951988328 @default.
• W2170110588 hasRelatedWork W383619729 @default.

• next