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- W2170111375 abstract "Despite the well-established role of heterochromatin in protecting chromosomal integrity during meiosis and mitosis, the contribution and extent of heterochromatic histone posttranslational modifications (PTMs) remain poorly defined. Here, we gained novel functional insight about heterochromatic PTMs by analyzing histone H3 purified from the heterochromatic germline micronucleus of the model organism Tetrahymena thermophila. Mass spectrometric sequencing of micronuclear H3 identified H3K23 trimethylation (H3K23me3), a previously uncharacterized PTM. H3K23me3 became particularly enriched during meiotic leptotene and zygotene in germline chromatin of Tetrahymena and C. elegans. Loss of H3K23me3 in Tetrahymena through deletion of the methyltransferase Ezl3p caused mislocalization of meiosis-induced DNA double-strand breaks (DSBs) to heterochromatin, and a decrease in progeny viability. These results show that an evolutionarily conserved developmental pathway regulates H3K23me3 during meiosis, and our studies in Tetrahymena suggest this pathway may function to protect heterochromatin from DSBs." @default.
- W2170111375 created "2016-06-24" @default.
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- W2170111375 date "2014-08-26" @default.
- W2170111375 modified "2023-10-17" @default.
- W2170111375 title "Methylation of histone H3K23 blocks DNA damage in pericentric heterochromatin during meiosis" @default.
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- W2170111375 doi "https://doi.org/10.7554/elife.02996" @default.
- W2170111375 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4141274" @default.
- W2170111375 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25161194" @default.