Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170147220> ?p ?o ?g. }
- W2170147220 endingPage "85" @default.
- W2170147220 startingPage "76" @default.
- W2170147220 abstract "Scleroderma is a skin disorder characterized by persistent fibrosis. Macrophage properties influencing cutaneous fibrogenesis remain to be fully elucidated. In this rat (F344 rats) model of scleroderma, at 1, 2, 3, and 4 weeks after initiation of daily subcutaneous injections of bleomycin (BLM; 100 μl of 1 mg/ml daily), skin samples were collected for histological and immunohistochemical evaluations. Immunohistochemically, the numbers of cells reacting to ED1 (anti-CD68; phagocytic activity) and ED2 (anti-CD163; inflammatory factor production) began to increase at week 1, peaked at week 2, and decreased thereafter. In contrast, the increased number of cells reacting to OX6 (anti–MHC class II molecules) was seen from week 2 and remained elevated until week 4. α–Smooth muscle actin–positive myofibroblasts were increased for 4 weeks. Double labeling revealed that galectin-3, a regulator of fibrogenic factor TGF-β1, was expressed in CD68+, CD163+, and MHC class II+ macrophages and myofibroblasts. mRNA expression of TGF-β1, as well as MCP-1 and CSF-1 (both macrophage function modulators), were significantly elevated at weeks 1 to 4. This study shows that the increased number of macrophages with heterogeneous immunophenotypes, which might be induced by MCP-1 and CSF-1, could participate in the sclerotic lesion formation, presumably through increased fibrogenic factors such as galectin-3 and TGF-β1; the data may provide useful information to understand the pathogenesis of the human scleroderma condition." @default.
- W2170147220 created "2016-06-24" @default.
- W2170147220 creator A5009514473 @default.
- W2170147220 creator A5018777099 @default.
- W2170147220 creator A5022863053 @default.
- W2170147220 creator A5035550385 @default.
- W2170147220 creator A5035894974 @default.
- W2170147220 creator A5068049495 @default.
- W2170147220 creator A5087481997 @default.
- W2170147220 date "2012-06-13" @default.
- W2170147220 modified "2023-09-25" @default.
- W2170147220 title "Immunophenotypical Characterization of Macrophages in Rat Bleomycin-Induced Scleroderma" @default.
- W2170147220 cites W1505584712 @default.
- W2170147220 cites W1514367558 @default.
- W2170147220 cites W1960367851 @default.
- W2170147220 cites W1964974360 @default.
- W2170147220 cites W1971779673 @default.
- W2170147220 cites W1971886057 @default.
- W2170147220 cites W1973631534 @default.
- W2170147220 cites W1987561261 @default.
- W2170147220 cites W1994988631 @default.
- W2170147220 cites W2017609056 @default.
- W2170147220 cites W2024291158 @default.
- W2170147220 cites W2028128714 @default.
- W2170147220 cites W2031551713 @default.
- W2170147220 cites W2032358585 @default.
- W2170147220 cites W2036438974 @default.
- W2170147220 cites W2043195959 @default.
- W2170147220 cites W2052895143 @default.
- W2170147220 cites W2056165131 @default.
- W2170147220 cites W2060182310 @default.
- W2170147220 cites W2061203824 @default.
- W2170147220 cites W2063677706 @default.
- W2170147220 cites W2065633957 @default.
- W2170147220 cites W2076982071 @default.
- W2170147220 cites W2078766605 @default.
- W2170147220 cites W2079891242 @default.
- W2170147220 cites W2079916634 @default.
- W2170147220 cites W2085056993 @default.
- W2170147220 cites W2093366741 @default.
- W2170147220 cites W2102815431 @default.
- W2170147220 cites W2114570899 @default.
- W2170147220 cites W2124572189 @default.
- W2170147220 cites W2128627731 @default.
- W2170147220 cites W2132715587 @default.
- W2170147220 cites W2134203448 @default.
- W2170147220 cites W2138211373 @default.
- W2170147220 cites W2139006852 @default.
- W2170147220 cites W2144108073 @default.
- W2170147220 cites W2144310026 @default.
- W2170147220 cites W2156674853 @default.
- W2170147220 cites W2165892104 @default.
- W2170147220 cites W2166508420 @default.
- W2170147220 cites W2170917916 @default.
- W2170147220 cites W2286829789 @default.
- W2170147220 doi "https://doi.org/10.1177/0300985812450718" @default.
- W2170147220 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22700848" @default.
- W2170147220 hasPublicationYear "2012" @default.
- W2170147220 type Work @default.
- W2170147220 sameAs 2170147220 @default.
- W2170147220 citedByCount "11" @default.
- W2170147220 countsByYear W21701472202013 @default.
- W2170147220 countsByYear W21701472202014 @default.
- W2170147220 countsByYear W21701472202015 @default.
- W2170147220 countsByYear W21701472202016 @default.
- W2170147220 countsByYear W21701472202018 @default.
- W2170147220 countsByYear W21701472202021 @default.
- W2170147220 crossrefType "journal-article" @default.
- W2170147220 hasAuthorship W2170147220A5009514473 @default.
- W2170147220 hasAuthorship W2170147220A5018777099 @default.
- W2170147220 hasAuthorship W2170147220A5022863053 @default.
- W2170147220 hasAuthorship W2170147220A5035550385 @default.
- W2170147220 hasAuthorship W2170147220A5035894974 @default.
- W2170147220 hasAuthorship W2170147220A5068049495 @default.
- W2170147220 hasAuthorship W2170147220A5087481997 @default.
- W2170147220 hasBestOaLocation W21701472201 @default.
- W2170147220 hasConcept C118131993 @default.
- W2170147220 hasConcept C126322002 @default.
- W2170147220 hasConcept C134018914 @default.
- W2170147220 hasConcept C142724271 @default.
- W2170147220 hasConcept C180032290 @default.
- W2170147220 hasConcept C185592680 @default.
- W2170147220 hasConcept C202751555 @default.
- W2170147220 hasConcept C203014093 @default.
- W2170147220 hasConcept C204232928 @default.
- W2170147220 hasConcept C207865475 @default.
- W2170147220 hasConcept C207936829 @default.
- W2170147220 hasConcept C2775858924 @default.
- W2170147220 hasConcept C2776232574 @default.
- W2170147220 hasConcept C2776460901 @default.
- W2170147220 hasConcept C2776694085 @default.
- W2170147220 hasConcept C2778814158 @default.
- W2170147220 hasConcept C2779244956 @default.
- W2170147220 hasConcept C2779967694 @default.
- W2170147220 hasConcept C2780559512 @default.
- W2170147220 hasConcept C2780942790 @default.
- W2170147220 hasConcept C55493867 @default.
- W2170147220 hasConcept C71924100 @default.