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• W2170147327 endingPage "1551" @default.
• W2170147327 startingPage "1543" @default.
• W2170147327 abstract "Interneuronal electrical coupling via gap junctions and chemical synaptic inhibitory transmission are known to have roles in the generation and synchronization of activity in neuronal networks. Uncertainty exists regarding the roles of these two modes of interneuronal communication in the central respiratory rhythm-generating system. To assess their roles, we performed studies on both the neonatal mouse medullary slice and en bloc brain stem-spinal cord preparations where rhythmic inspiratory motor activity can readily be recorded from both hypoglossal and phrenic nerve roots. The rhythmic inspiratory activity observed had two temporal characteristics: the basic respiratory frequency occurring on a long time scale and the synchronous neuronal discharge within the inspiratory burst occurring on a short time scale. In both preparations, we observed that bath application of gap-junction blockers, including 18 alpha-glycyrrhetinic acid, 18 beta-glycyrrhetinic acid, and carbenoxolone, all caused a reduction in respiratory frequency. In contrast, peak integrated phrenic and hypoglossal inspiratory activity was not significantly changed by gap-junction blockade. On a short-time-scale, gap-junction blockade increased the degree of synchronization within an inspiratory burst observed in both nerves. In contrast, opposite results were observed with blockade of GABA(A) and glycine receptors. We found that respiratory frequency increased with receptor blockade, and simultaneous blockade of both receptors consistently resulted in a reduction in short-time-scale synchronized activity observed in phrenic and hypoglossal inspiratory bursts. These results support the concept that the central respiratory system has two components: a rhythm generator responsible for the production of respiratory cycle timing and an inspiratory pattern generator that is involved in short-time-scale synchronization. In the neonatal rodent, properties of both components can be regulated by interneuronal communication via gap junctions and inhibitory synaptic transmission." @default.
• W2170147327 created "2016-06-24" @default.
• W2170147327 creator A5004126349 @default.
• W2170147327 creator A5009732461 @default.
• W2170147327 date "2001-04-01" @default.
• W2170147327 modified "2023-10-15" @default.
• W2170147327 title "Gap Junctions and Inhibitory Synapses Modulate Inspiratory Motoneuron Synchronization" @default.
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• W2170147327 doi "https://doi.org/10.1152/jn.2001.85.4.1543" @default.
• W2170147327 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11287478" @default.
• W2170147327 hasPublicationYear "2001" @default.
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