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• W2170147688 abstract "Recent reports have indicated that the cysteine protease activity of Der p 1 may play a significant role in its ability to elicit IgE antibody responses, mainly through cleavage of membrane CD23 on B cells and interleukin (IL)-4 synthesis and secretion from mast cells and basophils. Here we demonstrate for the first time that Der p 1 also cleaves the alpha subunit of the IL-2 receptor (IL-2R or CD25) from the surface of human peripheral blood T cells and, as a result, these cells show markedly diminished proliferation and interferon gamma secretion in response to potent stimulation by anti-CD3 antibody. Given that the IL-2R is pivotal for the propagation of Th1 cells, its cleavage by Der p 1 may consequently bias the immune response towards Th2 cells, thereby creating an allergic microenvironment." @default.
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• W2170147688 date "1998-01-19" @default.
• W2170147688 modified "2023-10-18" @default.
• W2170147688 title "Proteolytic Cleavage of CD25, the α Subunit of the Human T Cell Interleukin 2 Receptor, by Der p 1, a Major Mite Allergen with Cysteine Protease Activity" @default.
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• W2170147688 doi "https://doi.org/10.1084/jem.187.2.271" @default.
• W2170147688 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2212095" @default.
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