FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170206194> ?p ?o ?g. }

• W2170206194 abstract "Abstract Background Starvation triggers a complex array of adaptative metabolic responses including energy-metabolic responses, a process which must imply tissue specific alterations in gene expression and in which the liver plays a central role. The present study aimed to describe the evolution of global gene expression profiles in liver of 4-week-old male chickens during a 48 h fasting period using a chicken 20 K oligoarray. Results A large number of genes were modulated by fasting (3532 genes with a pvalue corrected by Benjamini-Hochberg < 0.01); 2062 showed an amplitude of variation higher than +/- 40% among those, 1162 presented an human ortholog, allowing to collect functional information. Notably more genes were down-regulated than up-regulated, whatever the duration of fasting (16 h or 48 h). The number of genes differentially expressed after 48 h of fasting was 3.5-fold higher than after 16 h of fasting. Four clusters of co-expressed genes were identified by a hierarchical cluster analysis. Gene Ontology, KEGG and Ingenuity databases were then used to identify the metabolic processes associated to each cluster. After 16 h of fasting, genes involved in ketogenesis, gluconeogenesis and mitochondrial or peroxisomal fatty acid beta-oxidation, were up-regulated (cluster-1) whereas genes involved in fatty acid and cholesterol synthesis were down-regulated (cluster-2). For all genes tested, the microarray data was confirmed by quantitative RT-PCR. Most genes were altered by fasting as already reported in mammals. A notable exception was the HMG-CoA synthase 1 gene, which was up-regulated following 16 and 48 h of fasting while the other genes involved in cholesterol metabolism were down-regulated as reported in mammalian studies. We further focused on genes not represented on the microarray and candidates for the regulation of the target genes belonging to cluster-1 and -2 and involved in lipid metabolism. Data are provided concerning PPARa, SREBP1, SREBP2, NR1H3 transcription factors and two desaturases (FADS1, FADS2). Conclusion This study evidences numerous genes altered by starvation in chickens and suggests a global repression of cellular activity in response to this stressor. The central role of lipid and acetyl-CoA metabolisms and its regulation at transcriptional level are confirmed in chicken liver in response to short-term fasting. Interesting expression modulations were observed for NR1H3, FADS1 and FADS2 genes. Further studies are needed to precise their role in the complex regulatory network controlling lipid metabolism." @default.
• W2170206194 created "2016-06-24" @default.
• W2170206194 creator A5001959821 @default.
• W2170206194 creator A5003198132 @default.
• W2170206194 creator A5003998584 @default.
• W2170206194 creator A5005467044 @default.
• W2170206194 creator A5022595373 @default.
• W2170206194 creator A5023993462 @default.
• W2170206194 creator A5024866533 @default.
• W2170206194 creator A5039837752 @default.
• W2170206194 creator A5065791509 @default.
• W2170206194 creator A5072570498 @default.
• W2170206194 creator A5073228322 @default.
• W2170206194 creator A5073788081 @default.
• W2170206194 creator A5074637174 @default.
• W2170206194 date "2008-12-01" @default.
• W2170206194 modified "2023-10-18" @default.
• W2170206194 title "Transcriptome profiling of the feeding-to-fasting transition in chicken liver" @default.
• W2170206194 cites W1505404389 @default.
• W2170206194 cites W1526348057 @default.
• W2170206194 cites W1593573576 @default.
• W2170206194 cites W1599210974 @default.
• W2170206194 cites W160527898 @default.
• W2170206194 cites W1875092895 @default.
• W2170206194 cites W1909989768 @default.
• W2170206194 cites W1967286688 @default.
• W2170206194 cites W1967939830 @default.
• W2170206194 cites W1968659767 @default.
• W2170206194 cites W1973139225 @default.
• W2170206194 cites W1975962309 @default.
• W2170206194 cites W1984418452 @default.
• W2170206194 cites W1995577794 @default.
• W2170206194 cites W1997559051 @default.
• W2170206194 cites W1999342925 @default.
• W2170206194 cites W2000213387 @default.
• W2170206194 cites W2001396094 @default.
• W2170206194 cites W2003967338 @default.
• W2170206194 cites W2009577529 @default.
• W2170206194 cites W2009624930 @default.
• W2170206194 cites W2016211755 @default.
• W2170206194 cites W2017220654 @default.
• W2170206194 cites W2024217191 @default.
• W2170206194 cites W2024851295 @default.
• W2170206194 cites W2028782957 @default.
• W2170206194 cites W2030859489 @default.
• W2170206194 cites W2034046497 @default.
• W2170206194 cites W2038617148 @default.
• W2170206194 cites W2040735050 @default.
• W2170206194 cites W2042002053 @default.
• W2170206194 cites W2043871660 @default.
• W2170206194 cites W2044702695 @default.
• W2170206194 cites W2044926535 @default.
• W2170206194 cites W2051883615 @default.
• W2170206194 cites W2052677026 @default.
• W2170206194 cites W2053938869 @default.
• W2170206194 cites W2059179695 @default.
• W2170206194 cites W2061864595 @default.
• W2170206194 cites W2067333453 @default.
• W2170206194 cites W2070630113 @default.
• W2170206194 cites W2081098333 @default.
• W2170206194 cites W2085779307 @default.
• W2170206194 cites W2086482588 @default.
• W2170206194 cites W2100668965 @default.
• W2170206194 cites W2101284986 @default.
• W2170206194 cites W2103017472 @default.
• W2170206194 cites W2103116278 @default.
• W2170206194 cites W2104399312 @default.
• W2170206194 cites W2106518631 @default.
• W2170206194 cites W2107261609 @default.
• W2170206194 cites W2110438479 @default.
• W2170206194 cites W2112460321 @default.
• W2170206194 cites W2115420718 @default.
• W2170206194 cites W2116016140 @default.
• W2170206194 cites W2116351973 @default.
• W2170206194 cites W2129223779 @default.
• W2170206194 cites W2129747400 @default.
• W2170206194 cites W2133208346 @default.
• W2170206194 cites W2138247507 @default.
• W2170206194 cites W2145820796 @default.
• W2170206194 cites W2146814107 @default.
• W2170206194 cites W2147156983 @default.
• W2170206194 cites W2147427406 @default.
• W2170206194 cites W2149744096 @default.
• W2170206194 cites W2152105936 @default.
• W2170206194 cites W2156396916 @default.
• W2170206194 cites W2162558399 @default.
• W2170206194 cites W2165674132 @default.
• W2170206194 cites W2171835397 @default.
• W2170206194 cites W2283164498 @default.
• W2170206194 cites W2413470331 @default.
• W2170206194 cites W2463961430 @default.
• W2170206194 cites W4242629133 @default.
• W2170206194 cites W4253834263 @default.
• W2170206194 cites W98247596 @default.
• W2170206194 doi "https://doi.org/10.1186/1471-2164-9-611" @default.
• W2170206194 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2628918" @default.
• W2170206194 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19091074" @default.
• W2170206194 hasPublicationYear "2008" @default.
• W2170206194 type Work @default.
• W2170206194 sameAs 2170206194 @default.

• next