FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170222758> ?p ?o ?g. }

• W2170222758 endingPage "M182" @default.
• W2170222758 startingPage "M176" @default.
• W2170222758 abstract "Aging is accompanied by decreased bone and lean body mass, increased fat mass, and reduced growth hormone (GH) axis function, reflected in diminished levels of insulin-like growth factor-I (IGF-I). Similar changes in body composition occur in nonelderly, GH-deficient adults and are reversible with GH administration, suggesting that diminished GH/IGF-I axis activity may contribute to such age-related changes. To determine the precise pattern of IGF-I decline with age, and to test the hypothesis that this decline is related to concomitant changes in body composition and bone metabolism independent of age, we conducted a cross-sectional survey in 351 healthy participants in the Baltimore Longitudinal Study of Aging.We evaluated relationships among IGF-I, age, and total and regional adiposity, as assessed by body mass index (BMI) and waist-to-hip ratio (WHR); lean body mass, as estimated from urinary creatinine excretion (Crex/ht); bone mineral density (BMD), as assessed by single and dual photon absorptiometry scanning; and circulating levels of parathyroid hormone (PTH), 1,25-(OH)2 D3, 25-OHD, and osteocalcin.Serum IGF-I levels declined with age (p < .0001) in both men (r = -.51) and women (r = -.67). In men, the decline was linear, whereas IGF-I levels decreased faster in women < 45 years of age than in older women (p < .01) or in men (p < .001). IGF-I was inversely related to BMI (p < .005), WHR (p < .001), and PTH (p < .01) in women. IGF-I was positively related to BMD of the hip and radius in both genders (p < .0003) and to Crex/ht (p < .0005) and osteocalcin (p < .0001) in men. With increasing age, Crex/ht and BMD decreased (p < .0001) and WHR, PTH, and osteocalcin increased (p < .005) in both genders, whereas BMI increased only in women (p < .005). After adjustment for age, IGF-I was not significantly related to BMI, WHR, Crex/ht, or BMD in either gender. IGF-I was positively related to 1,25-(OH)2 D3 (p < .01) independently of age in women.Advancing age, rather than declining serum levels of IGF-I, appears to be a major determinant of life-time changes in body composition and BMD in women and men." @default.
• W2170222758 created "2016-06-24" @default.
• W2170222758 creator A5007874741 @default.
• W2170222758 creator A5024112287 @default.
• W2170222758 creator A5040085433 @default.
• W2170222758 creator A5065812257 @default.
• W2170222758 creator A5068665691 @default.
• W2170222758 creator A5072543383 @default.
• W2170222758 creator A5079428284 @default.
• W2170222758 date "1998-05-01" @default.
• W2170222758 modified "2023-10-10" @default.
• W2170222758 title "Serum Levels of Insulin-like Growth Factor-I Are Related to Age and Not to Body Composition in Healthy Women and Men" @default.
• W2170222758 cites W1853647023 @default.
• W2170222758 cites W1975831468 @default.
• W2170222758 cites W1984426897 @default.
• W2170222758 cites W1985356497 @default.
• W2170222758 cites W2008440547 @default.
• W2170222758 cites W2011227211 @default.
• W2170222758 cites W2016576879 @default.
• W2170222758 cites W2019582539 @default.
• W2170222758 cites W2027490051 @default.
• W2170222758 cites W2032503802 @default.
• W2170222758 cites W2034380697 @default.
• W2170222758 cites W2041203073 @default.
• W2170222758 cites W2041673999 @default.
• W2170222758 cites W2049287362 @default.
• W2170222758 cites W2049864407 @default.
• W2170222758 cites W2054548024 @default.
• W2170222758 cites W2054654084 @default.
• W2170222758 cites W2054889739 @default.
• W2170222758 cites W2055397537 @default.
• W2170222758 cites W2058462436 @default.
• W2170222758 cites W2060824379 @default.
• W2170222758 cites W2062369866 @default.
• W2170222758 cites W2064869610 @default.
• W2170222758 cites W2064910660 @default.
• W2170222758 cites W2072013077 @default.
• W2170222758 cites W2087952899 @default.
• W2170222758 cites W2089086406 @default.
• W2170222758 cites W2100488282 @default.
• W2170222758 cites W2108626793 @default.
• W2170222758 cites W2111823915 @default.
• W2170222758 cites W2121639043 @default.
• W2170222758 cites W2134792323 @default.
• W2170222758 cites W2145640646 @default.
• W2170222758 cites W2151906675 @default.
• W2170222758 cites W2165675667 @default.
• W2170222758 cites W2315987042 @default.
• W2170222758 cites W2413121481 @default.
• W2170222758 cites W2417971356 @default.
• W2170222758 cites W2136863973 @default.
• W2170222758 doi "https://doi.org/10.1093/gerona/53a.3.m176" @default.
• W2170222758 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9597048" @default.
• W2170222758 hasPublicationYear "1998" @default.
• W2170222758 type Work @default.
• W2170222758 sameAs 2170222758 @default.
• W2170222758 citedByCount "97" @default.
• W2170222758 countsByYear W21702227582012 @default.
• W2170222758 countsByYear W21702227582013 @default.
• W2170222758 countsByYear W21702227582014 @default.
• W2170222758 countsByYear W21702227582015 @default.
• W2170222758 countsByYear W21702227582016 @default.
• W2170222758 countsByYear W21702227582017 @default.
• W2170222758 countsByYear W21702227582018 @default.
• W2170222758 countsByYear W21702227582019 @default.
• W2170222758 countsByYear W21702227582020 @default.
• W2170222758 countsByYear W21702227582021 @default.
• W2170222758 countsByYear W21702227582022 @default.
• W2170222758 countsByYear W21702227582023 @default.
• W2170222758 crossrefType "journal-article" @default.
• W2170222758 hasAuthorship W2170222758A5007874741 @default.
• W2170222758 hasAuthorship W2170222758A5024112287 @default.
• W2170222758 hasAuthorship W2170222758A5040085433 @default.
• W2170222758 hasAuthorship W2170222758A5065812257 @default.
• W2170222758 hasAuthorship W2170222758A5068665691 @default.
• W2170222758 hasAuthorship W2170222758A5072543383 @default.
• W2170222758 hasAuthorship W2170222758A5079428284 @default.
• W2170222758 hasConcept C120863210 @default.
• W2170222758 hasConcept C126322002 @default.
• W2170222758 hasConcept C131075544 @default.
• W2170222758 hasConcept C134018914 @default.
• W2170222758 hasConcept C147583825 @default.
• W2170222758 hasConcept C160160445 @default.
• W2170222758 hasConcept C170493617 @default.
• W2170222758 hasConcept C181199279 @default.
• W2170222758 hasConcept C2775960820 @default.
• W2170222758 hasConcept C2776193436 @default.
• W2170222758 hasConcept C2780221984 @default.
• W2170222758 hasConcept C2780689927 @default.
• W2170222758 hasConcept C33997684 @default.
• W2170222758 hasConcept C500499127 @default.
• W2170222758 hasConcept C55493867 @default.
• W2170222758 hasConcept C71924100 @default.
• W2170222758 hasConcept C86803240 @default.
• W2170222758 hasConceptScore W2170222758C120863210 @default.
• W2170222758 hasConceptScore W2170222758C126322002 @default.
• W2170222758 hasConceptScore W2170222758C131075544 @default.
• W2170222758 hasConceptScore W2170222758C134018914 @default.

• next