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- W2170229658 abstract "Cultured human lymphoma cells exposed to adriamycin exhibited extreme sensitivity to the drug. When these cells were exposed to adriamycin for 12 hr, a 5-log kill in terms of reproductive capacity was observed. Furthermore, under these conditions, adriamycin exerted an immediate (interphase) lethal effect on about 60% of the cells. Synchronized cells revealed that the S-G2 boundary region was the most sensitive stage of the cell cycle. Insofar as adriamycin can achieve a great killing effect at low doses and with short exposure times, we suggest that a superior clinical therapeutic index could be achieved by utilizing adequately spaced low doses of adriamycin in the treatment of human tumors." @default.
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- W2170229658 date "1973-06-01" @default.
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- W2170229658 title "Survival kinetics of cultured human lymphoma cells exposed to adriamycin." @default.
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