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- W2170231421 abstract "Recent progress in the measurement of intravascular blood gas tensions by mass spectrometry [8, 13] is of potential interest in the study of placental gas exchange, because the mass spectrometer allows continuous measurement of both p02 and pC02. The determination of blood gases by conventional techniques, which mostly require blood sampling, has contributed significantly to the investigation of placental gas exchange [6, 11, 16]. Mass spectrometry, however, can give important additional Information about the kinetics of transplacental gas exchange. The guinea pig is an important model in placental research, because its discoid, haemomonochorial placenta resembles that of man [7]. Hitherto, the study of placental gas exchange in this species has been limited, because conventional methods of gas analysis require blood samples that are large in relation to the blood volume of the fetus. In the present study, we have investigated the feasibility of monitoring the blood gases of fetal guinea pigs by mass spectrometry, using an intravascular probe developed for this purpose [13]. Simultaneous and continuous measurements of p02 and pC02 in the right atrium of the fetuses were made before, during and after an acute change in maternal placental blood flow provoked by an infusion of noradrenaline. Curriculum vitae" @default.
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- W2170231421 date "1982-01-01" @default.
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- W2170231421 title "Continuous measurement of blood gas tensions in the fetal guinea pig by mass spectrometry" @default.
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- W2170231421 doi "https://doi.org/10.1515/jpme.1982.10.5.226" @default.
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