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- W2170231656 abstract "A physical model for genetic stability of DNA is constructed in terms of the “microscopic” model for uninduced point mutations and the electromechanical thermoelastic properties of the macroscopic “global” DNA system. Theoretical considerations show how experimental data from one of the least complicated but useful genetic systems, T4 bacteriophage, support the proton-code model of DNA discussed by Löwdin. The stability of an unperturbed DNA system is treated to illustrate the dynamical coupling between the “global” motion of DNA and the stability at local genetic sites. The method for analyzing a DNA system perturbed by “low-energy” optical or acoustical frequencies is indicated. The model provides a physical explanation for “hot spots” (genetic sites highly susceptible to mutation) and suggests that quantum theory may be as useful in the biological sciences as it is in the physical sciences with respect to designing and interpreting certain experiments in genetics. The incidence of human cancer as a function of chronological age is discussed in terms of the model." @default.
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- W2170231656 date "1978-07-01" @default.
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- W2170231656 title "Theory of mutations. II. Physical model of genetic stability" @default.
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- W2170231656 doi "https://doi.org/10.1002/qua.560140108" @default.
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