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• W2170233935 startingPage "32320" @default.
• W2170233935 abstract "Endo180/urokinase plasminogen activator receptor-associated protein together with the mannose receptor, the phospholipase A₂ receptor, and DEC-205/MR6-gp200 comprise the four members of the mannose receptor family. These receptors have a unique structural composition due to the presence of multiple C-type lectin-like domains within a single polypeptide backbone. In addition, they are all constitutively internalized from the plasma membrane via clathrin-mediated endocytosis and recycled back to the cell surface. Endo180 is a multifunctional receptor displaying Ca²⁺-dependent lectin activity, collagen binding, and association with the urokinase plasminogen activator receptor, and it has a proposed role in extracellular matrix degradation and remodeling. Within their short cytoplasmic domains, all four receptors contain both a conserved tyrosine-based and dihydrophobic-based putative endocytosis motif. Unexpectedly, Endo180 was found to be distinct within the family in that the tyrosine-based motif is not required for efficient delivery to and recycling from early endosomes. By contrast, receptor internalization is completely dependent on the dihydrophobic motif and modulated by a conserved upstream acidic residue. Furthermore, unlike the mannose receptor, Endo180 does not function as a phagocytic receptor <i>in vitro</i>. These findings demonstrate that despite an overall structural similarity, members of this receptor family employ distinct trafficking mechanisms that may reflect important differences in their physiological functions." @default.
• W2170233935 created "2016-06-24" @default.
• W2170233935 creator A5050881123 @default.
• W2170233935 creator A5061098872 @default.
• W2170233935 date "2002-08-01" @default.
• W2170233935 modified "2023-10-11" @default.
• W2170233935 title "The C-type Lectin Receptor Endo180 Displays Internalization and Recycling Properties Distinct from Other Members of the Mannose Receptor Family" @default.
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• W2170233935 doi "https://doi.org/10.1074/jbc.m203631200" @default.
• W2170233935 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12068012" @default.
• W2170233935 hasPublicationYear "2002" @default.
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