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- W2170248839 abstract "The development of therapeutic cancer vaccines is impacted by immunosuppressive elements in the tumor microenvironment. Most immunogenic cancer proteins are self, therefore, peripheral tolerance contributes substantially to tumor immune escape. Transforming growth factor beta (TGFbeta) actively modulates both inflammation and tolerance induction. Combining vaccination with agents that disarm TGFbeta will enhance vaccine efficacy." @default.
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- W2170248839 date "2009-11-01" @default.
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- W2170248839 title "Enhancing Cancer Vaccine Efficacy via Modulation of the Tumor Microenvironment" @default.
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- W2170248839 doi "https://doi.org/10.1158/1078-0432.ccr-09-2256" @default.
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