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- W2170249908 endingPage "e0004082" @default.
- W2170249908 startingPage "e0004082" @default.
- W2170249908 abstract "Echinostoma caproni (Trematoda: Echinostomatidae) is an intestinal trematode that has been extensively used as experimental model to investigate the factors determining the expulsion of intestinal helminths or, in contrast, the development of chronic infections. Herein, we analyze the changes in protein expression induced by E. caproni infection in ICR mice, a host of high compatibility in which the parasites develop chronic infections.To determine the changes in protein expression, a two-dimensional DIGE approach using protein extracts from the intestine of naïve and infected mice was employed; and spots showing significant differential expression were analyzed by mass spectrometry. A total of 37 spots were identified differentially expressed in infected mice (10 were found to be over-expressed and 27 down-regulated). These proteins were related to the restoration of the intestinal epithelium and the control of homeostatic dysregulation, concomitantly with mitochondrial and cytoskeletal proteins among others.Our results suggests that changes in these processes in the ileal epithelium of ICR mice may facilitate the establishment of the parasite and the development of chronic infections. These results may serve to explain the factors determining the development of chronicity in intestinal helminth infection." @default.
- W2170249908 created "2016-06-24" @default.
- W2170249908 creator A5033140840 @default.
- W2170249908 creator A5034954374 @default.
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- W2170249908 creator A5067018046 @default.
- W2170249908 creator A5071410567 @default.
- W2170249908 creator A5089834805 @default.
- W2170249908 date "2015-09-21" @default.
- W2170249908 modified "2023-10-15" @default.
- W2170249908 title "Altered Protein Expression in the Ileum of Mice Associated with the Development of Chronic Infections with Echinostoma caproni (Trematoda)" @default.
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