FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170250797> ?p ?o ?g. }

• W2170250797 endingPage "398" @default.
• W2170250797 startingPage "389" @default.
• W2170250797 abstract "Aging diminishes myogenic tone in arterioles from skeletal muscle. Recent evidence indicates that both large-conductance Ca2+-activated (BKCa) and voltage-dependent (KV) K+ channels mediate negative feedback control of the myogenic response. Thus we tested the hypothesis that aging increases the contributions of KV and BKCa channels to myogenic regulation of vascular tone. Because myogenic responsiveness differs between oxidative and glycolytic muscles, we predicted that KV and BKCa channel contributions to myogenic responsiveness vary with fiber type. Myogenic responses of first-order arterioles from the gastrocnemius and soleus muscles of 4- and 24-mo-old Fischer 344 rats were evaluated in the presence and absence of 4-aminopyridine (5 mM) or iberiotoxin (30 nM), inhibitors of KV and BKCa, respectively. 4-Aminopyridine enhanced myogenic tone with aging and normalized age-related differences in both muscle types. By contrast, iberiotoxin eliminated age-related differences in soleus arterioles and had no effect in gastrocnemius vessels. KV1.5 is an integral component of KV channels in vascular smooth muscle; therefore, we determined the relative protein expression of KV1.5, as well as BKCa, in soleus and gastrocnemius arterioles. Immunoblot analysis revealed no differences in KV1.5 protein with aging or between variant fiber types, whereas BKCa protein levels declined with age in arterioles from both muscle groups. Collectively, these results suggest that the contribution of BKCa to myogenic regulation of vascular tone changes with age in soleus muscle arterioles, whereas increased KV channel expression and negative feedback regulation of myogenic tone increases with advancing age in arterioles from both oxidative and glycolytic muscles." @default.
• W2170250797 created "2016-06-24" @default.
• W2170250797 creator A5038570981 @default.
• W2170250797 creator A5058711932 @default.
• W2170250797 creator A5058916727 @default.
• W2170250797 creator A5075473131 @default.
• W2170250797 creator A5085806985 @default.
• W2170250797 creator A5089025967 @default.
• W2170250797 date "2009-08-01" @default.
• W2170250797 modified "2023-10-11" @default.
• W2170250797 title "Aging and muscle fiber type alter K⁺ channel contributions to the myogenic response in skeletal muscle arterioles" @default.
• W2170250797 cites W149798078 @default.
• W2170250797 cites W1508504160 @default.
• W2170250797 cites W1575561688 @default.
• W2170250797 cites W1753089048 @default.
• W2170250797 cites W1964003759 @default.
• W2170250797 cites W1972617290 @default.
• W2170250797 cites W1998157660 @default.
• W2170250797 cites W2005348430 @default.
• W2170250797 cites W2005398406 @default.
• W2170250797 cites W2018505579 @default.
• W2170250797 cites W2019024024 @default.
• W2170250797 cites W2019536000 @default.
• W2170250797 cites W2071969879 @default.
• W2170250797 cites W2087211815 @default.
• W2170250797 cites W2092434590 @default.
• W2170250797 cites W2098963973 @default.
• W2170250797 cites W2100082306 @default.
• W2170250797 cites W2101722224 @default.
• W2170250797 cites W2102952069 @default.
• W2170250797 cites W2104848153 @default.
• W2170250797 cites W2113413190 @default.
• W2170250797 cites W2117242701 @default.
• W2170250797 cites W2117271758 @default.
• W2170250797 cites W2117707422 @default.
• W2170250797 cites W2130140191 @default.
• W2170250797 cites W2139379183 @default.
• W2170250797 cites W2146345914 @default.
• W2170250797 cites W2149635665 @default.
• W2170250797 cites W2149714769 @default.
• W2170250797 cites W2153726188 @default.
• W2170250797 cites W2153834368 @default.
• W2170250797 cites W2162025202 @default.
• W2170250797 cites W2167102952 @default.
• W2170250797 cites W2171525560 @default.
• W2170250797 cites W2176470771 @default.
• W2170250797 cites W2178269751 @default.
• W2170250797 cites W2178854470 @default.
• W2170250797 cites W2181620390 @default.
• W2170250797 cites W2188833261 @default.
• W2170250797 cites W2208409969 @default.
• W2170250797 cites W2213081838 @default.
• W2170250797 cites W2299508194 @default.
• W2170250797 cites W2398999363 @default.
• W2170250797 doi "https://doi.org/10.1152/japplphysiol.91245.2008" @default.
• W2170250797 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2724325" @default.
• W2170250797 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19407249" @default.
• W2170250797 hasPublicationYear "2009" @default.
• W2170250797 type Work @default.
• W2170250797 sameAs 2170250797 @default.
• W2170250797 citedByCount "42" @default.
• W2170250797 countsByYear W21702507972012 @default.
• W2170250797 countsByYear W21702507972013 @default.
• W2170250797 countsByYear W21702507972014 @default.
• W2170250797 countsByYear W21702507972015 @default.
• W2170250797 countsByYear W21702507972016 @default.
• W2170250797 countsByYear W21702507972017 @default.
• W2170250797 countsByYear W21702507972018 @default.
• W2170250797 countsByYear W21702507972019 @default.
• W2170250797 countsByYear W21702507972020 @default.
• W2170250797 countsByYear W21702507972021 @default.
• W2170250797 countsByYear W21702507972022 @default.
• W2170250797 countsByYear W21702507972023 @default.
• W2170250797 crossrefType "journal-article" @default.
• W2170250797 hasAuthorship W2170250797A5038570981 @default.
• W2170250797 hasAuthorship W2170250797A5058711932 @default.
• W2170250797 hasAuthorship W2170250797A5058916727 @default.
• W2170250797 hasAuthorship W2170250797A5075473131 @default.
• W2170250797 hasAuthorship W2170250797A5085806985 @default.
• W2170250797 hasAuthorship W2170250797A5089025967 @default.
• W2170250797 hasBestOaLocation W21702507972 @default.
• W2170250797 hasConcept C105702510 @default.
• W2170250797 hasConcept C126322002 @default.
• W2170250797 hasConcept C134018914 @default.
• W2170250797 hasConcept C185592680 @default.
• W2170250797 hasConcept C207200792 @default.
• W2170250797 hasConcept C2775872116 @default.
• W2170250797 hasConcept C2776104385 @default.
• W2170250797 hasConcept C2779395532 @default.
• W2170250797 hasConcept C2779411790 @default.
• W2170250797 hasConcept C2779959927 @default.
• W2170250797 hasConcept C2992686903 @default.
• W2170250797 hasConcept C3763915 @default.
• W2170250797 hasConcept C58336856 @default.
• W2170250797 hasConcept C71924100 @default.
• W2170250797 hasConcept C83743174 @default.
• W2170250797 hasConcept C86803240 @default.
• W2170250797 hasConceptScore W2170250797C105702510 @default.

• next