FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170260537> ?p ?o ?g. }

• W2170260537 endingPage "444" @default.
• W2170260537 startingPage "443" @default.
• W2170260537 abstract "Transglutaminases may be involved in intestinal inflammation and may even represent therapeutic targets for ulcerative colitisThe family of transglutaminases (TG) includes the plasma form factor XIIIa as well as the tissue transglutaminase (tTG) and keratinocyte transglutaminase (TGk). In particular, tTG reminds every gastroenterologist primarily of coeliac disease where tTG represents the key autoantigen.1 Disease induction is confined to tTG, a ubiquitous enzyme which is released from fibroblasts, endothelial, and inflammatory cells during mechanical irritation or inflammation. At acidic pH, which occurs with inflammation, tTG can, apart from its physiological function described in more detail below, also simply deamidate some of the glutamine residues of the gluten peptides. In coeliac disease, deamidation introduces a negative charge into the gluten peptides which can increase the binding affinity to HLA-DQ2 or HLA-DQ8, the primary HLA association in coeliac disease. Binding of gluten peptide to either HLA-DQ2 or HLA-DQ8 results in an increase in their capacity to stimulate T cells, thus inducing intestinal inflammation.2,3As indicated in this issue of Gut by D’Argenio and colleagues,4 TG may be involved in intestinal inflammation in a completely different way and may even represent a therapeutic target (see page 496) . But how can the physiological function of TG be defined? TG are enzymes catalysing the covalent cross linking between proteins by forming e(γ-glutamyl)-lysine isopeptide bonds. These bonds are formed between glutaminase and lysine residues thus stabilising intra- and extracellular proteins, a process which is required for a variety of essential physiological purposes such as barrier function in epithelia, apoptosis, and extracellular matrix formation.5 Substrates include intracellular (actin cytoskeleton, histones) as well as extracellular (collagen, vitronectin, fibronectin) …" @default.
• W2170260537 created "2016-06-24" @default.
• W2170260537 creator A5031092899 @default.
• W2170260537 creator A5031972677 @default.
• W2170260537 date "2005-04-01" @default.
• W2170260537 modified "2023-09-30" @default.
• W2170260537 title "Transglutaminases: new target molecules for inflammatory bowel disease?" @default.
• W2170260537 cites W1800141310 @default.
• W2170260537 cites W1967455040 @default.
• W2170260537 cites W1975891446 @default.
• W2170260537 cites W1992641427 @default.
• W2170260537 cites W1993194125 @default.
• W2170260537 cites W2040124176 @default.
• W2170260537 cites W2056868752 @default.
• W2170260537 cites W2073079404 @default.
• W2170260537 cites W2074906766 @default.
• W2170260537 cites W2077417036 @default.
• W2170260537 cites W2082014143 @default.
• W2170260537 cites W2095003217 @default.
• W2170260537 cites W2112006012 @default.
• W2170260537 cites W2141301636 @default.
• W2170260537 cites W2146353544 @default.
• W2170260537 cites W2148072458 @default.
• W2170260537 cites W2162869700 @default.
• W2170260537 cites W2417319557 @default.
• W2170260537 doi "https://doi.org/10.1136/gut.2004.053223" @default.
• W2170260537 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1774453" @default.
• W2170260537 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15753520" @default.
• W2170260537 hasPublicationYear "2005" @default.
• W2170260537 type Work @default.
• W2170260537 sameAs 2170260537 @default.
• W2170260537 citedByCount "2" @default.
• W2170260537 countsByYear W21702605372022 @default.
• W2170260537 crossrefType "journal-article" @default.
• W2170260537 hasAuthorship W2170260537A5031092899 @default.
• W2170260537 hasAuthorship W2170260537A5031972677 @default.
• W2170260537 hasBestOaLocation W21702605371 @default.
• W2170260537 hasConcept C126322002 @default.
• W2170260537 hasConcept C2777572184 @default.
• W2170260537 hasConcept C2778260677 @default.
• W2170260537 hasConcept C2779134260 @default.
• W2170260537 hasConcept C71924100 @default.
• W2170260537 hasConceptScore W2170260537C126322002 @default.
• W2170260537 hasConceptScore W2170260537C2777572184 @default.
• W2170260537 hasConceptScore W2170260537C2778260677 @default.
• W2170260537 hasConceptScore W2170260537C2779134260 @default.
• W2170260537 hasConceptScore W2170260537C71924100 @default.
• W2170260537 hasIssue "4" @default.
• W2170260537 hasLocation W21702605371 @default.
• W2170260537 hasLocation W21702605372 @default.
• W2170260537 hasLocation W21702605373 @default.
• W2170260537 hasLocation W21702605374 @default.
• W2170260537 hasLocation W21702605375 @default.
• W2170260537 hasOpenAccess W2170260537 @default.
• W2170260537 hasPrimaryLocation W21702605371 @default.
• W2170260537 hasRelatedWork W154415141 @default.
• W2170260537 hasRelatedWork W1989568804 @default.
• W2170260537 hasRelatedWork W2052065748 @default.
• W2170260537 hasRelatedWork W2075334414 @default.
• W2170260537 hasRelatedWork W2156758733 @default.
• W2170260537 hasRelatedWork W2314098491 @default.
• W2170260537 hasRelatedWork W2408939568 @default.
• W2170260537 hasRelatedWork W3134857862 @default.
• W2170260537 hasRelatedWork W3209514756 @default.
• W2170260537 hasRelatedWork W4232531751 @default.
• W2170260537 hasVolume "54" @default.
• W2170260537 isParatext "false" @default.
• W2170260537 isRetracted "false" @default.
• W2170260537 magId "2170260537" @default.
• W2170260537 workType "article" @default.