FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170260871> ?p ?o ?g. }

• W2170260871 endingPage "2658" @default.
• W2170260871 startingPage "2650" @default.
• W2170260871 abstract "ABSTRACT Staf is a transcriptional activator of prime importance for enhanced transcription of small nuclear (snRNA) and snRNA-type genes transcribed by RNA polymerases II and III (Pol II and III). In addition to this activity, it also possesses the capacity to stimulate expression from an RNA polymerase II mRNA promoter. This promiscuous activator thus provides a useful model system for studying the mechanism by which one single transcription factor can activate a large variety of promoters. Here, we report the use of in vivo assays to identify the Staf activation domains involved in promoter selectivity. Analysis of Staf mutants reveals the existence of two physically and functionally distinct regions, outside of the DNA binding domain, responsible for mediating selective transcriptional activation. While a 93-amino-acid domain, with the striking presence of four repeated units, is specialized for transcriptional activation of an mRNA promoter, a segment of only 18 amino acids, with a critical Leu-213 residue, acts specifically on Pol II and Pol III snRNA and snRNA-type promoters. In addition, this study disclosed the fundamental importance of invariant leucine and aspartic acid residues located in each repeat unit of the mRNA activation domain. Staf is therefore the first transcriptional activator described so far to harbor two physically and functionally distinct activator domains. This finding suggests that the same activator can contact different, specialized transcription complexes formed on different types of basal promoters through promoter-specific transactivation pathways." @default.
• W2170260871 created "2016-06-24" @default.
• W2170260871 creator A5038993090 @default.
• W2170260871 creator A5049411069 @default.
• W2170260871 creator A5084312705 @default.
• W2170260871 date "1998-05-01" @default.
• W2170260871 modified "2023-10-14" @default.
• W2170260871 title "Two Distinct Domains in Staf To Selectively Activate Small Nuclear RNA-Type and mRNA Promoters" @default.
• W2170260871 cites W1004177858 @default.
• W2170260871 cites W119076594 @default.
• W2170260871 cites W1450500198 @default.
• W2170260871 cites W1517442337 @default.
• W2170260871 cites W1607233960 @default.
• W2170260871 cites W179941649 @default.
• W2170260871 cites W1836876093 @default.
• W2170260871 cites W1958059146 @default.
• W2170260871 cites W1976261939 @default.
• W2170260871 cites W1976852255 @default.
• W2170260871 cites W1979800592 @default.
• W2170260871 cites W1995272144 @default.
• W2170260871 cites W1999210446 @default.
• W2170260871 cites W2001046931 @default.
• W2170260871 cites W2005914718 @default.
• W2170260871 cites W2006141036 @default.
• W2170260871 cites W2016676541 @default.
• W2170260871 cites W2018916132 @default.
• W2170260871 cites W2020772198 @default.
• W2170260871 cites W2021825316 @default.
• W2170260871 cites W2042425655 @default.
• W2170260871 cites W2045622916 @default.
• W2170260871 cites W2047634049 @default.
• W2170260871 cites W2048293070 @default.
• W2170260871 cites W2051713854 @default.
• W2170260871 cites W2068577315 @default.
• W2170260871 cites W2070119588 @default.
• W2170260871 cites W2077783035 @default.
• W2170260871 cites W2087950896 @default.
• W2170260871 cites W2089111392 @default.
• W2170260871 cites W2092098896 @default.
• W2170260871 cites W2092205160 @default.
• W2170260871 cites W2095450147 @default.
• W2170260871 cites W2101852310 @default.
• W2170260871 cites W2106036374 @default.
• W2170260871 cites W2117272440 @default.
• W2170260871 cites W2126719129 @default.
• W2170260871 cites W2135905023 @default.
• W2170260871 cites W2151639225 @default.
• W2170260871 cites W2153017169 @default.
• W2170260871 cites W2161585446 @default.
• W2170260871 cites W2163683961 @default.
• W2170260871 cites W2164099611 @default.
• W2170260871 cites W2210241620 @default.
• W2170260871 cites W2231322698 @default.
• W2170260871 cites W2080943356 @default.
• W2170260871 doi "https://doi.org/10.1128/mcb.18.5.2650" @default.
• W2170260871 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/110644" @default.
• W2170260871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9566884" @default.
• W2170260871 hasPublicationYear "1998" @default.
• W2170260871 type Work @default.
• W2170260871 sameAs 2170260871 @default.
• W2170260871 citedByCount "34" @default.
• W2170260871 countsByYear W21702608712012 @default.
• W2170260871 countsByYear W21702608712013 @default.
• W2170260871 countsByYear W21702608712015 @default.
• W2170260871 countsByYear W21702608712020 @default.
• W2170260871 countsByYear W21702608712021 @default.
• W2170260871 countsByYear W21702608712022 @default.
• W2170260871 crossrefType "journal-article" @default.
• W2170260871 hasAuthorship W2170260871A5038993090 @default.
• W2170260871 hasAuthorship W2170260871A5049411069 @default.
• W2170260871 hasAuthorship W2170260871A5084312705 @default.
• W2170260871 hasBestOaLocation W21702608711 @default.
• W2170260871 hasConcept C100299639 @default.
• W2170260871 hasConcept C101762097 @default.
• W2170260871 hasConcept C104317684 @default.
• W2170260871 hasConcept C1292079 @default.
• W2170260871 hasConcept C138885662 @default.
• W2170260871 hasConcept C144825837 @default.
• W2170260871 hasConcept C150194340 @default.
• W2170260871 hasConcept C153911025 @default.
• W2170260871 hasConcept C172768829 @default.
• W2170260871 hasConcept C179926584 @default.
• W2170260871 hasConcept C194993378 @default.
• W2170260871 hasConcept C41895202 @default.
• W2170260871 hasConcept C54355233 @default.
• W2170260871 hasConcept C64350747 @default.
• W2170260871 hasConcept C67705224 @default.
• W2170260871 hasConcept C86803240 @default.
• W2170260871 hasConcept C88045685 @default.
• W2170260871 hasConcept C95444343 @default.
• W2170260871 hasConceptScore W2170260871C100299639 @default.
• W2170260871 hasConceptScore W2170260871C101762097 @default.
• W2170260871 hasConceptScore W2170260871C104317684 @default.
• W2170260871 hasConceptScore W2170260871C1292079 @default.
• W2170260871 hasConceptScore W2170260871C138885662 @default.
• W2170260871 hasConceptScore W2170260871C144825837 @default.
• W2170260871 hasConceptScore W2170260871C150194340 @default.
• W2170260871 hasConceptScore W2170260871C153911025 @default.

• next