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• W2170280329 endingPage "1949" @default.
• W2170280329 startingPage "1940" @default.
• W2170280329 abstract "The eukaryotic transcriptional repressor PRDI-BF1 contains five zinc fingers of the C2H2 type, and the protein binds specifically to PRDI, a 14-bp regulatory element of the beta interferon gene promoter. We have investigated the amino acid sequence requirements for specific binding to PRDI and found that the five zinc fingers and a short stretch of amino acids N terminal to the first finger are necessary and sufficient for PRDI-specific binding. The contribution of individual zinc fingers to DNA binding was investigated by inserting them in various combinations into another zinc finger-containing DNA-binding protein whose own fingers had been removed. We found that insertion of PRDI-BF1 zinc fingers 1 and 2 confer PRDI-binding activity on the recipient protein. In contrast, the insertion of PRDI-BF1 zinc fingers 2 through 5, the insertion of zinc finger 1 or 2 alone, and the insertion of zinc fingers 1 and 2 in reverse order did not confer PRDI-binding activity. We conclude that the first two PRDI-BF1 zinc fingers together are sufficient for the sequence-specific recognition of PRDI." @default.
• W2170280329 created "2016-06-24" @default.
• W2170280329 creator A5062059600 @default.
• W2170280329 creator A5091116725 @default.
• W2170280329 date "1992-05-01" @default.
• W2170280329 modified "2023-09-25" @default.
• W2170280329 title "Only two of the five zinc fingers of the eukaryotic transcriptional repressor PRDI-BF1 are required for sequence-specific DNA binding." @default.
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• W2170280329 doi "https://doi.org/10.1128/mcb.12.5.1940" @default.
• W2170280329 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/364364" @default.
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