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- W2170291018 abstract "HIV-1 infection can now be readily controlled with combination antiretroviral therapy. However, the virus persists indefinitely in a stable latent reservoir in resting CD4(+) T cells. This reservoir generally prevents cure of the infection with combination antiretroviral therapy alone. However, several recent cases of potential HIV-1 cure have generated renewed optimism. Here we review these cases and consider new developments in our understanding of the latent reservoir. In addition, we consider clinical aspects of curative strategies to provide a more realistic picture of what a generally applicable cure for HIV-1 infection is likely to entail." @default.
- W2170291018 created "2016-06-24" @default.
- W2170291018 creator A5014454124 @default.
- W2170291018 creator A5079324608 @default.
- W2170291018 date "2014-07-01" @default.
- W2170291018 modified "2023-10-11" @default.
- W2170291018 title "Recent developments in the search for a cure for HIV-1 infection: Targeting the latent reservoir for HIV-1" @default.
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- W2170291018 doi "https://doi.org/10.1016/j.jaci.2014.05.026" @default.
- W2170291018 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25117799" @default.
- W2170291018 hasPublicationYear "2014" @default.
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