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• W2170292044 endingPage "e005732" @default.
• W2170292044 startingPage "e005732" @default.
• W2170292044 abstract "<h3>Objectives</h3> Overweight and obesity is a problem in children in particular and determining pathways of transmission is important in prevention. We aimed to examine associations for body mass index (BMI) across three generations of the same families. <h3>Participants</h3> Members of 556 families in the Lifeways Cross-Generation Cohort Study 2001–2014. <h3>Setting</h3> Community-based study with linkage to health records in the Republic of Ireland. <h3>Methods</h3> Employing a novel mixed-method approach which adjusts for age and familial group, BMI correlations were estimated at three ages of the index child, that is, at birth and at ages 5 and 9. Height was also examined for comparative purposes. <h3>Results</h3> Correlation of offspring9s BMI with that of the mother increased with age (correlation coefficient 0.15 increasing to 0.28, p value <0.001 in all cases) while no consistent pattern was seen with offspring and fathers. There was an association also with each parent and their own mother. Offspring9s BMI was correlated to a lesser extent with that of the maternal grandmother while for girls only there was an association with that of the paternal grandmother at ages 0 and 5 (correlation coefficients 0.25, 0.28, p values 0.02, 0.01, respectively). In contrast, height of the child was strongly associated with those of all family members at age 5, but at birth and at age 9 only there was an association with those of the parents and the paternal grandfather. Correlation of offspring9s height with those of the mother and father increased with age. <h3>Conclusions</h3> The results suggest that BMI is predominantly associated with the maternal line, possibly either with intrauterine development, or inherited through the X chromosome, or both, while height is a more complex trait with genetic influences of the parents and that of the paternal grandfather predominating." @default.
• W2170292044 created "2016-06-24" @default.
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• W2170292044 date "2014-12-01" @default.
• W2170292044 modified "2023-10-17" @default.
• W2170292044 title "Body mass index is associated with the maternal lines but height is heritable across family lines in the Lifeways Cross-Generation Cohort Study" @default.
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• W2170292044 doi "https://doi.org/10.1136/bmjopen-2014-005732" @default.
• W2170292044 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4275682" @default.
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• W2170292044 hasPublicationYear "2014" @default.
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