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• W2170298006 abstract "This paper identifies a multidimensional random switched process model of a neuron with embedded Ca++ ion channel and pump molecules adiabatically interacting based on local ion concentrations near the cell membrane. The model interprets known physiology of the channels as a coupled set of switched random processes and derives mechanical equations based on concentration flow among different states of the system. Rapid changes to channel barrier energies occurring during channel opening and closing transitions are modeled as another degree of freedom commutating the state of the overall system. An ion reservoir model is used as the primary tool to incorporate stochastic effects in channel operation. The complete model is analyzed numerically and then the equations are used to motivate a stochastic model for closed state dwell times. The result is compared against expected results of a leaky-integrator and known single-channel histograms." @default.
• W2170298006 created "2016-06-24" @default.
• W2170298006 creator A5068747992 @default.
• W2170298006 date "2007-08-01" @default.
• W2170298006 modified "2023-09-27" @default.
• W2170298006 title "Cellular ion channel-pump system modeling using switched stochastic differential equations" @default.
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• W2170298006 doi "https://doi.org/10.1109/iembs.2007.4352494" @default.
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