Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170314373> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2170314373 endingPage "663" @default.
- W2170314373 startingPage "661" @default.
- W2170314373 abstract "Cerebrospinal fluid (CSF) fistulas occur mainly in basal skull fractures or operations at the skull base entailing a dural defect; up to 40% of CSF fistulas are spontaneous (1). The treatment consists of surgical closure of the dural defect. Complications such as intracranial abscess or bacterial meningitis may develop, with a mortality rate of 25–50%. Therefore, a simple and reliable diagnosis of CSF fistulas is of great importance.β-Trace protein is synthesized mainly in the epithelial cells of the choroid plexus and is found in CSF in concentrations ∼35-fold higher than in plasma (2). Thus, β-trace protein represents a potentially useful marker for the diagnosis of CSF leakage (3), with immunoelectrophoresis having a specificity of 100% and a sensitivity of 91% for the diagnosis of CSF leakage (4).β2-Transferrin, the asialo form of transferrin, is produced by neuraminidase activity in the brain and is usually detectable only in CSF, perilymph, and aqueous humor. Thus, like β-trace protein, it is a potentially useful marker to diagnose CSF leakage (3).In the present work we compared the first two commercially available assay systems: a new, sensitive immunofixation method from Sebia GmbH for detection of β2-transferrin and an automatic, quantitative immunonephelometric assay from Dade Behring for detection of β-trace protein. We also established a cutoff value for β-trace protein and evaluated the potential of both markers as indicators of CSF leakage.The β-trace protein assay is based on latex particle enhancement using rabbit polyclonal antibodies against β-trace protein. Calibrators contain β-trace protein purified from CSF (N Protein Standard UY®; Dade Behring). Imprecision was assessed by assaying N/T protein Control LC® (Dade Behring). Measurements were performed on a BN …" @default.
- W2170314373 created "2016-06-24" @default.
- W2170314373 creator A5001345731 @default.
- W2170314373 creator A5012151068 @default.
- W2170314373 creator A5024876863 @default.
- W2170314373 creator A5044825212 @default.
- W2170314373 creator A5054560791 @default.
- W2170314373 creator A5081149806 @default.
- W2170314373 date "2004-03-01" @default.
- W2170314373 modified "2023-09-30" @default.
- W2170314373 title "Comparison of β2-Transferrin and β-Trace Protein for Detection of Cerebrospinal Fluid in Nasal and Ear Fluids" @default.
- W2170314373 cites W2018333861 @default.
- W2170314373 cites W2029332640 @default.
- W2170314373 cites W2084175921 @default.
- W2170314373 cites W2085168428 @default.
- W2170314373 cites W2091188285 @default.
- W2170314373 cites W2325430391 @default.
- W2170314373 cites W4298878256 @default.
- W2170314373 cites W4366064133 @default.
- W2170314373 doi "https://doi.org/10.1373/clinchem.2003.024158" @default.
- W2170314373 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14981039" @default.
- W2170314373 hasPublicationYear "2004" @default.
- W2170314373 type Work @default.
- W2170314373 sameAs 2170314373 @default.
- W2170314373 citedByCount "60" @default.
- W2170314373 countsByYear W21703143732012 @default.
- W2170314373 countsByYear W21703143732013 @default.
- W2170314373 countsByYear W21703143732014 @default.
- W2170314373 countsByYear W21703143732015 @default.
- W2170314373 countsByYear W21703143732016 @default.
- W2170314373 countsByYear W21703143732017 @default.
- W2170314373 countsByYear W21703143732018 @default.
- W2170314373 countsByYear W21703143732019 @default.
- W2170314373 countsByYear W21703143732020 @default.
- W2170314373 countsByYear W21703143732021 @default.
- W2170314373 countsByYear W21703143732022 @default.
- W2170314373 countsByYear W21703143732023 @default.
- W2170314373 crossrefType "journal-article" @default.
- W2170314373 hasAuthorship W2170314373A5001345731 @default.
- W2170314373 hasAuthorship W2170314373A5012151068 @default.
- W2170314373 hasAuthorship W2170314373A5024876863 @default.
- W2170314373 hasAuthorship W2170314373A5044825212 @default.
- W2170314373 hasAuthorship W2170314373A5054560791 @default.
- W2170314373 hasAuthorship W2170314373A5081149806 @default.
- W2170314373 hasBestOaLocation W21703143731 @default.
- W2170314373 hasConcept C126322002 @default.
- W2170314373 hasConcept C138885662 @default.
- W2170314373 hasConcept C142724271 @default.
- W2170314373 hasConcept C22814914 @default.
- W2170314373 hasConcept C2779651940 @default.
- W2170314373 hasConcept C33619753 @default.
- W2170314373 hasConcept C41895202 @default.
- W2170314373 hasConcept C71924100 @default.
- W2170314373 hasConcept C75291252 @default.
- W2170314373 hasConceptScore W2170314373C126322002 @default.
- W2170314373 hasConceptScore W2170314373C138885662 @default.
- W2170314373 hasConceptScore W2170314373C142724271 @default.
- W2170314373 hasConceptScore W2170314373C22814914 @default.
- W2170314373 hasConceptScore W2170314373C2779651940 @default.
- W2170314373 hasConceptScore W2170314373C33619753 @default.
- W2170314373 hasConceptScore W2170314373C41895202 @default.
- W2170314373 hasConceptScore W2170314373C71924100 @default.
- W2170314373 hasConceptScore W2170314373C75291252 @default.
- W2170314373 hasIssue "3" @default.
- W2170314373 hasLocation W21703143731 @default.
- W2170314373 hasLocation W21703143732 @default.
- W2170314373 hasOpenAccess W2170314373 @default.
- W2170314373 hasPrimaryLocation W21703143731 @default.
- W2170314373 hasRelatedWork W136906409 @default.
- W2170314373 hasRelatedWork W1503832999 @default.
- W2170314373 hasRelatedWork W1982519190 @default.
- W2170314373 hasRelatedWork W2056539414 @default.
- W2170314373 hasRelatedWork W2091968832 @default.
- W2170314373 hasRelatedWork W2170314373 @default.
- W2170314373 hasRelatedWork W2400599040 @default.
- W2170314373 hasRelatedWork W2796267954 @default.
- W2170314373 hasRelatedWork W2182771847 @default.
- W2170314373 hasRelatedWork W2518773715 @default.
- W2170314373 hasVolume "50" @default.
- W2170314373 isParatext "false" @default.
- W2170314373 isRetracted "false" @default.
- W2170314373 magId "2170314373" @default.
- W2170314373 workType "article" @default.