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- W2170314841 abstract "To study how much the side chains of the corrin ring of vitamin B12 are involved in the physiological roles of the vitamin, five vitamin B12 analogues (cyanocobalamin-b-monocarboxylate, cyanocobalamin-d-monocarboxylate, cyanocobalamin-e-monocarboxylate, cyano-13-epicobalamin, and cyanocobalamin(c-lactam)) with alternations in the side chains were synthesized chemically and then administered orally and intravenously to vitamin B12-deficient rats. Male rats fed a vitamin B12-deficient diet for 11 wk developed a severe vitamin B12 deficiency with a high urinary methylmalonate excretion (223.8 ± 136.2 μmol/d) and ~97% (1.2±0.7ng/g tissue) lower hepatic vitamin B12 content. Oral and intravenous administration of cyanocobalamin-b-,-d-, and -e-monocarboxylates and cyano-13-epicobalamin could not improve the severe vitamin B12-deficient status of the rats, indicating that the b-, d-, and e-propionamide side chains of the corrin ring of vitamin B12 are important in the absorption, transport, and function of the vi..." @default.
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- W2170314841 date "1993-01-01" @default.
- W2170314841 modified "2023-09-27" @default.
- W2170314841 title "Effects of Vitamin B12Analogues with Alternations in the Side Chains of the Corrin Ring on Urinary Methylmalonate Excretion in Vitamin B12-Deficient Rats" @default.
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- W2170314841 doi "https://doi.org/10.1271/bbb.57.607" @default.
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