FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170332008> ?p ?o ?g. }

• W2170332008 endingPage "260" @default.
• W2170332008 startingPage "255" @default.
• W2170332008 abstract "ObjectiveTo evaluate the cost-effectiveness of adjuvant FOLFOX therapy versus 5-fluorouracil/leucovorin (FU/LV) for patients with stage III colorectal cancer.MethodsWe performed the cost-effectiveness of FOLFOX compared with standard FU/LV treatment by the retrospective analysis of patient-level data from the randomized controlled Multicenter International Study of Oxaliplatin, 5-Fluorouracil, and Leucovorin in the Adjuvant Treatment of Colon Cancer (MOSAIC) trial. Predicted mean time spent in each disease state was calculated by our statistical model, which takes into account the cure rate and treats death from causes other than colon cancer as a competing risk. We performed this analysis from the perspective of the health-care payer. Using a time horizon of 30 years, both cost and effectiveness were discounted by 3% per year.ResultsEstimated cure rates for colon cancer were 0.715 (FOLFOX) and 0.622 (FU/LV). Estimated medical costs of FOLFOX were JPY 3.1 million (USD 34,000) compared with JPY 1.9 million (USD 22,000) of FU/LV. The mean estimated quality-adjusted life-year was 9.83 with FOLFOX and 9.07 with that of FU/LV. The incremental cost-effectiveness ratio of FOLFOX was JPY 1.5 million (USD 17,000) per quality-adjusted life-year compared with FU/LV, which was supported by sensitivity analysis. Even if we assume that Japanese outcomes were better than those reported by the MOSAIC trial, which would reduce the difference between cure rates for each treatment to 5%, the incremental cost-effectiveness ratio remained below 5.0 million (USD 56,000) per quality-adjusted life-year.ConclusionsAdjuvant FOLFOX is a cost-effective treatment for stage III colon cancer in Japan compared with FU/LV therapy. Even when parameters were changed to reflect smaller improvements with FOLFOX, the conclusion is the same." @default.
• W2170332008 created "2016-06-24" @default.
• W2170332008 creator A5004765985 @default.
• W2170332008 creator A5007564965 @default.
• W2170332008 creator A5027221459 @default.
• W2170332008 creator A5055351763 @default.
• W2170332008 creator A5090955736 @default.
• W2170332008 date "2012-03-01" @default.
• W2170332008 modified "2023-10-15" @default.
• W2170332008 title "Cost-Effectiveness of Adjuvant FOLFOX Therapy for Stage III Colon Cancer in Japan Based on the MOSAIC Trial" @default.
• W2170332008 cites W1845706120 @default.
• W2170332008 cites W1962875322 @default.
• W2170332008 cites W1974783008 @default.
• W2170332008 cites W1976873809 @default.
• W2170332008 cites W1993453162 @default.
• W2170332008 cites W2029738571 @default.
• W2170332008 cites W2043951092 @default.
• W2170332008 cites W2061896525 @default.
• W2170332008 cites W2118950501 @default.
• W2170332008 cites W2119440126 @default.
• W2170332008 cites W2121368761 @default.
• W2170332008 cites W2144495943 @default.
• W2170332008 cites W2171232394 @default.
• W2170332008 cites W2469345929 @default.
• W2170332008 cites W4211147392 @default.
• W2170332008 doi "https://doi.org/10.1016/j.jval.2011.10.006" @default.
• W2170332008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22433756" @default.
• W2170332008 hasPublicationYear "2012" @default.
• W2170332008 type Work @default.
• W2170332008 sameAs 2170332008 @default.
• W2170332008 citedByCount "15" @default.
• W2170332008 countsByYear W21703320082013 @default.
• W2170332008 countsByYear W21703320082014 @default.
• W2170332008 countsByYear W21703320082015 @default.
• W2170332008 countsByYear W21703320082016 @default.
• W2170332008 countsByYear W21703320082017 @default.
• W2170332008 countsByYear W21703320082021 @default.
• W2170332008 countsByYear W21703320082022 @default.
• W2170332008 countsByYear W21703320082023 @default.
• W2170332008 crossrefType "journal-article" @default.
• W2170332008 hasAuthorship W2170332008A5004765985 @default.
• W2170332008 hasAuthorship W2170332008A5007564965 @default.
• W2170332008 hasAuthorship W2170332008A5027221459 @default.
• W2170332008 hasAuthorship W2170332008A5055351763 @default.
• W2170332008 hasAuthorship W2170332008A5090955736 @default.
• W2170332008 hasBestOaLocation W21703320081 @default.
• W2170332008 hasConcept C112930515 @default.
• W2170332008 hasConcept C121608353 @default.
• W2170332008 hasConcept C126322002 @default.
• W2170332008 hasConcept C141071460 @default.
• W2170332008 hasConcept C143998085 @default.
• W2170332008 hasConcept C159110408 @default.
• W2170332008 hasConcept C168563851 @default.
• W2170332008 hasConcept C2778260052 @default.
• W2170332008 hasConcept C2779951463 @default.
• W2170332008 hasConcept C2780456651 @default.
• W2170332008 hasConcept C2780962732 @default.
• W2170332008 hasConcept C3019080777 @default.
• W2170332008 hasConcept C526805850 @default.
• W2170332008 hasConcept C71924100 @default.
• W2170332008 hasConceptScore W2170332008C112930515 @default.
• W2170332008 hasConceptScore W2170332008C121608353 @default.
• W2170332008 hasConceptScore W2170332008C126322002 @default.
• W2170332008 hasConceptScore W2170332008C141071460 @default.
• W2170332008 hasConceptScore W2170332008C143998085 @default.
• W2170332008 hasConceptScore W2170332008C159110408 @default.
• W2170332008 hasConceptScore W2170332008C168563851 @default.
• W2170332008 hasConceptScore W2170332008C2778260052 @default.
• W2170332008 hasConceptScore W2170332008C2779951463 @default.
• W2170332008 hasConceptScore W2170332008C2780456651 @default.
• W2170332008 hasConceptScore W2170332008C2780962732 @default.
• W2170332008 hasConceptScore W2170332008C3019080777 @default.
• W2170332008 hasConceptScore W2170332008C526805850 @default.
• W2170332008 hasConceptScore W2170332008C71924100 @default.
• W2170332008 hasIssue "2" @default.
• W2170332008 hasLocation W21703320081 @default.
• W2170332008 hasLocation W21703320082 @default.
• W2170332008 hasOpenAccess W2170332008 @default.
• W2170332008 hasPrimaryLocation W21703320081 @default.
• W2170332008 hasRelatedWork W1978017914 @default.
• W2170332008 hasRelatedWork W2037039278 @default.
• W2170332008 hasRelatedWork W2136984368 @default.
• W2170332008 hasRelatedWork W2138294834 @default.
• W2170332008 hasRelatedWork W2235788479 @default.
• W2170332008 hasRelatedWork W2297296679 @default.
• W2170332008 hasRelatedWork W2569965908 @default.
• W2170332008 hasRelatedWork W2809146871 @default.
• W2170332008 hasRelatedWork W3110357236 @default.
• W2170332008 hasRelatedWork W3140349894 @default.
• W2170332008 hasVolume "15" @default.
• W2170332008 isParatext "false" @default.
• W2170332008 isRetracted "false" @default.
• W2170332008 magId "2170332008" @default.
• W2170332008 workType "article" @default.