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• W2170336877 endingPage "497" @default.
• W2170336877 startingPage "488" @default.
• W2170336877 abstract "ABSTRACT A widely distributed family of small regulators, called C proteins, controls a subset of restriction-modification systems. The C proteins studied to date activate transcription of their own genes and that of downstream endonuclease genes; this arrangement appears to delay endonuclease expression relative to that of the protective methyltransferase when the genes enter a new cell. C proteins bind to conserved sequences called C boxes. In the PvuII system, the C boxes have been reported to extend from −23 to +3 relative to the transcription start for the gene for the C protein, an unexpected starting position relative to a bound activator. This study suggests that transcript initiation within the C boxes represents initial, C-independent transcription of pvuIICR . The major C protein-dependent transcript appears to be a leaderless mRNA starting farther downstream, at the initiation codon for the pvuIIC gene. This conclusion is based on nuclease S1 transcript mapping and the effects of a series of nested deletions in the promoter region. Furthermore, replacing the region upstream of the pvuIIC initiation codon with a library of random oligonucleotides, followed by selection for C-dependent transcription, yielded clones having sequences that resemble −10 promoter hexamers. The −35 hexamer of this promoter would lie within the C boxes. However, the spacing between C boxes/−35 and the apparent −10 hexamer can be varied by ±4 bp with little effect. This suggests that, like some other activator-dependent promoters, P pvuIICR may not require a −35 hexamer. Features of this transcription activation system suggest explanations for its broad host range." @default.
• W2170336877 created "2016-06-24" @default.
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• W2170336877 creator A5070145317 @default.
• W2170336877 date "2005-01-15" @default.
• W2170336877 modified "2023-10-13" @default.
• W2170336877 title "Nature of the Promoter Activated by C.PvuII, an Unusual Regulatory Protein Conserved among Restriction-Modification Systems" @default.
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• W2170336877 doi "https://doi.org/10.1128/jb.187.2.488-497.2005" @default.
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