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• W2170348510 abstract "Breast cancer is the most common non-cutaneous cancer (29%) and the second highest cause of cancer deaths (16%, second only to lung cancer) among women in the US [ 1 Landis S.H. Murray T. Bolden S. Wingo P.A. Cancer Statistics, 1999. CA Cancer J. Clin. 1999; 49: 8-31 Crossref PubMed Scopus (3113) Google Scholar ]. Despite advances in the treatment of breast cancer and a recent downward trend in breast cancer mortality with a levelling off of breast cancer incidence [ 1 Landis S.H. Murray T. Bolden S. Wingo P.A. Cancer Statistics, 1999. CA Cancer J. Clin. 1999; 49: 8-31 Crossref PubMed Scopus (3113) Google Scholar , 2 Mettlin C. Global breast cancer mortality statistics. CA Cancer J. Clin. 1999; 49: 138-144 Crossref PubMed Scopus (140) Google Scholar ], this disease remains a major public health problem, prompting increasing emphasis on early detection and prevention. The oestrogen responsiveness of breast tumours suggested the use of a therapeutic antagonist to the action of oestrogen, a selective oestrogen receptor modulator, or SERM, in the prevention of breast cancer [ 3 Jordan V.C. Breast cancer prevention in the primary care setting. Primary Care & Cancer. 1999; 19: 9-10 Google Scholar ]. Accumulating evidence from breast cancer treatment trials pointed to the ability of the first SERM, tamoxifen, to prevent second primary breast cancers in the contralateral breast in women being treated in the adjuvant setting for established invasive disease [ 4 Breast Cancer Trials Committee, Scottish Cancer Trials Office (MRC), Edinburgh: adjuvant tamoxifen in the management of operable breast cancer: the Scottish trial. Lancet 1987, 2, 171–175. Google Scholar , 5 Rutqvist L.E. Cedermark B. Glas U. et al. The Stockholm trial on adjuvant tamoxifen in early breast cancer. Breast Cancer Res. Treat. 1987; 10: 255-266 Crossref PubMed Scopus (111) Google Scholar , 6 Fisher B. Costantino J. Redmond C. Poisson R. et al. Randomized clinical trial evaluating tamoxifen in the treatment of patients with node-negative breast cancer who have estrogen receptor-positive tumors. N. Engl. J. Med. 1989; 320: 479-484 Crossref PubMed Scopus (1289) Google Scholar , 7 Nayfield S.G. Karp J.E. Ford L.G. et al. Potential role of tamoxifen in prevention of breast cancer. J. Natl. Cancer Inst. 1991; 83: 1450-1459 Crossref PubMed Scopus (381) Google Scholar , 8 Ragaz J. Coldman A. Survival impact of adjuvant tamoxifen on competing causes of mortality in breast cancer survivors, with analysis of mortality from contralateral breast cancer, cardiovascular events, endometrial cancer, and thromboembolic episodes. J. Clin. Oncol. 1998; 16: 2018-2024 PubMed Google Scholar ]." @default.
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• W2170348510 title "Breast cancer prevention: results of the National Surgical Adjuvant Breast and Bowel Project (NSABP) breast cancer prevention trial (NSABP P-1: BCPT)" @default.
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• W2170348510 doi "https://doi.org/10.1016/s0959-8049(00)00223-9" @default.
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