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- W2170362509 abstract "Objective: To explore the properties of the Silverstein Microwick ® Background: Direct drug delivery to the inner ear via the round window membrane is becoming increasingly common. The Silverstein Microwick is an example of a sustained release delivery system. Medication regimens for this wick have largely been chosen arbitrarily as there is no data relating to its inner ear kinetic profile and no knowledge of its wicking behavior. Methods: A custom-built device was used to measure electrical impedances obtained from a series of 6 electrodes inserted into a Silverstein Microwick in order to define the time course of how different parts of the wick dry out. The impedances across adjoining pairs of electrodes were used to measure the “wetness” of each segment. Three drops of gentamicin solution were applied. We sought to determine the flow of the solutions through the wick by analyzing changes in electrical impedance. Various medications were applied to the wick including dexamethasone. Other properties inherent to the wick were also measured including drug availability at the round window membrane end and its filtering capacity. Results: It was determined that the wick was completely dry after 105-110 minutes and that it dried faster at its extremities. The electrical impedance of the rwm end of the wick reached its pre-test level after 100-105 minutes. However, drug availability at the rwm end of the wick ceased after 70-75 minutes. Adding a further 3 drops after 1 hour prolonged the drying time by 100 minutes. A 15% elevation in environmental humidity resulted in a drying time of 400 minutes. Liquid suspensions were not ideal for use through the wick as components of suspensions are retained by the wick material. Suspensions were also found to have the highest viscosities. Conclusion: The most therapeutic inner ear profile for treatment of Meniere’s is unknown. Although pumps can be used to generate any kind of profile, they are not currently licensed for use in humans and are invasive and expensive. The Silverstein microwick has been used successfully in humans and is non-invasive and cheap. Only inner ear studies will be able to determine their exact inner ear kinetic profile associated with this device. However, the profiles achievable with this device will largely be determined and ultimately limited by the behavior/ characteristics of the wick. Our study sheds light on this. Given that drug availability to the round window membrane is 70-75 minutes we can surmise the most likely inner ear kinetic profile that would ensue. The dosing regimen for the microwick could be altered to influence this. Inner ear studies are required to determine if changes in wick dosing parallel events in the inner ear." @default.
- W2170362509 created "2016-06-24" @default.
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- W2170362509 date "2015-09-23" @default.
- W2170362509 modified "2023-10-14" @default.
- W2170362509 title "The Wicking Characteristics of a Sustained Release Delivery System for the Inner Ear: The Silverstein Micro Wick" @default.
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- W2170362509 doi "https://doi.org/10.15406/joentr.2015.03.00068" @default.
- W2170362509 hasPublicationYear "2015" @default.
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