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• W2170370440 abstract "No AccessJournal of UrologyClinical Urology: Original Articles1 Jan 1998THERAPEUTIC EFFECTS OF HIGH DOSE YOHIMBINE HYDROCHLORIDE ON ORGANIC ERECTILE DYSFUNCTION Claudio Teloken, Ernani Luis Rhoden, Paulo Sogari, Miriam Dambros, and Carlos Ary Vargas Souto Claudio TelokenClaudio Teloken More articles by this author , Ernani Luis RhodenErnani Luis Rhoden More articles by this author , Paulo SogariPaulo Sogari More articles by this author , Miriam DambrosMiriam Dambros More articles by this author , and Carlos Ary Vargas SoutoCarlos Ary Vargas Souto More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)64032-1AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We evaluated men with organic erectile dysfunction treated with placebo and high dose oral yohimbine hydrochloride. Materials and Methods: We selected 22 patients with organic erectile dsyfunction (mean age 58 years) for treatment in the andrology outpatient clinic. These patients had been previously undergone neurological, vascular, hormonal and psychological testing, and were treated during an equal period of 30 days with placebo and daily single dose oral 100 mg. yohimbine. The response to treatment was evaluated via a questionnaire that comprised the outcome items of complete-normal penile rigidity enabling vaginal penetration, partial-erection improved but not sufficiently for appropriate vaginal penetration, none-no improvement and worse-erection deteriorated. The patients consented to treatment after being told of the severe adverse effects that might occur. Results: The most common side effects were anxiety, increase in cardiac frequency, increased urinary output and headache but in no case was treatment discontinued. Of the patients 3 (13.6%) and 12 (54.5%) reported complete or partial response to treatment, respectively. However, statistical analysis disclosed no significant difference when yohimbine was compared to placebo (p > .05). Conclusions: Oral 100 mg. single dose daily yohimbine promotes no improvement in patients with organic erectile dysfunction. References 1 : Catecholamines, sympathomimetic drugs, and adrenergic receptor antagonists.. In: The Pharmacological Basis of Therapeutics. Edited by . New York: McGraw-Hill1996: 199. Google Scholar 2 : Double blind trial of yohimbine hidrochloride in the treatment of erectil inadequacy.. J. Sex. Mar. Ther.1989; 4: 17. Google Scholar 3 : Yohimbine: a pharmacological probe for study of the adrenoreceptor.. Pharm. Rev.1983; 35: 143. Google Scholar 4 : Statistical summary of 10000 male cases using Afrodex in the treatment of impotence.. Curr. Ther. Res.1971; 13: 616. Google Scholar 5 : Is yohimbine effective in the treatment of organic impotence? Results of a controlled trial.. J. Urol.1987; 137: 1168. Abstract, Google Scholar 6 : Effects of yohimbine on human sympathetic nervous system function.. J. Endocr. Metab.1991; 73: 81. Google Scholar 7 : Effect of yohimbine on erectile impotence. A double blind study.. J. Urol.1989; 141: 1360. Abstract, Google Scholar 8 : Effect of yohimbine-trazodone on psychogenic impotence: a randomized, bouble-blind, placebo-controlled study.. Urology1994; 44: 732. Google Scholar 9 : Assessment of an adrenergic autorregulator function in humans: effects of oral Yohimbine.. Life Sci.1981; 30: 2033. Google Scholar 10 : Yohimbine induce anxiety and increased noradrenergic function in humans: effects of diazepan and clonidine.. Life Sci.1983; 33: 19. Google Scholar 11 : Three cases of maniac symptoms following Yohimbine administration.. Am. J. Psychiat.1984; 141: 1267. Google Scholar 12 : Practical treatise on disorders of sexual function of the male and female.. Ann. Clin. Med.1926; 4: 510. Google Scholar 13 : Review of studies on a mixture of nux vomica, yohimbine and methyl testosterone in the treatment of impotence.. Curr. Ther. Res.1966; 8: 280. Google Scholar 14 : Nonhormonal pharmacological treatment of impotence.. J. Urol.1982; 128: 45. Abstract, Google Scholar 15 : Double blind trial of yohimbine in the treatment of psycogenic impotence.. Lancet1987; 22: 8. Google Scholar 16 : The role of yohimbine for the treatment of erectile impotence.. J. Sex. Mar. Ther.1990; 169: 15. Google Scholar 17 : Anxiety increase sexual arousal.. J. Abn. Psychiat.1983; 92: 49. Google Scholar 18 Morales, A., Condra, M., Surridge, D. S. M., Fenemore, J. and Owen, J. A.: The effectiveness of yohimbine in the treatment of impotence: results of a controlled trial. Proceedings of the American Urological Association Meeting, A391, abstract, 1984. Google Scholar 19 : Uso terapeutico do hidroclorato de ioimbina em disfuncao eretil.. J. Bras. Urol.1991; 17: 19. Google Scholar 20 : Single cell activity in the noradrenergic A5 region: responses to drugs and peripheral manipulation of blood pressure.. Brain Res.1982; 242: 125. Google Scholar From the Department of Urology, Santa Casa Hospital and Fundacao Faculadade Federal of Ciencias Medicas, Porto Alegre, BrazilAccepted for publication June 20, 1997(Teloken) Requests for reprints: Av.Carlos Gomes 403/604 - Zip Code 90550-141, Porto Alegre, RS, Brazil© 1998 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 159Issue 1January 1998Page: 122-124 Advertisement Copyright & Permissions© 1998 by American Urological Association, Inc.MetricsAuthor Information Claudio Teloken More articles by this author Ernani Luis Rhoden More articles by this author Paulo Sogari More articles by this author Miriam Dambros More articles by this author Carlos Ary Vargas Souto More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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