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- W2170371010 abstract "Background:Previous studies have shown that angiotensin II AT1 receptor gene (AT1R) polymorphisms are associated with the risk for hypertension. However, the results remain controversial. In the present study, we performed a meta-analysis to systematically summarize the association between AT1R genetic polymorphisms and the risk for hypertension. Methods:We searched the literature in PubMed, EMBASE, ISI Web of Science, Wanfang, and Chinese National Knowledge Infrastructure databases (CNKI) to find case-control studies on the associations of AT1R genetic polymorphisms with the risk for hypertension. The meta-analysis was performed by using RevMan 5.0 software. The association of hypertension risk with AT1R genetic polymorphism was estimated by pooled odds ratios (ORs) and 95% confidence intervals (95% CIs). Results:Fifty-six studies involving 28,952 subjects were included in the present meta-analysis. Our results suggest that the polymorphism (A1166C) of AT1R gene is associated with a statistically increased hypertension risk, not only in Asian populations but also in Caucasian populations. We did not find any association in African populations. Conclusions:This meta-analysis suggests that A1166C polymorphism in the AT1R gene is associated with the risk of hypertension in Asian and Caucasian populations." @default.
- W2170371010 created "2016-06-24" @default.
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- W2170371010 date "2015-05-18" @default.
- W2170371010 modified "2023-09-23" @default.
- W2170371010 title "Association of <i>AT1R</i> polymorphism with hypertension risk: An update meta-analysis based on 28,952 subjects" @default.
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- W2170371010 doi "https://doi.org/10.1177/1470320315584096" @default.
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