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• W2170372276 abstract "The intrarenal autocrine-paracrine dopamine (DA) system is critical for Na + homeostasis. l-Dihydroxyphenylalanine (l-DOPA) uptake from the glomerular filtrate and plasma provides the substrate for DA generation by the renal proximal tubule. The transporter(s) responsible for proximal tubule l-DOPA uptake has not been characterized. Renal cortical poly-A + RNA injected into Xenopus laevis oocytes induced l-DOPA uptake in a time- and dose-dependent fashion with biphasic K m s in the millimolar and micromolar range and independent of inward Na + , K + , or H + gradients, suggesting the presence of low- and high-affinity l-DOPA carriers. Complementary RNA from two amino acid transporters yielded l-DOPA uptake significantly above water-injected controls the rBAT/b 0,+ AT dimer (rBAT) and the LAT2/4F2 dimer (LAT2). In contradistinction to renal cortical poly-A + , l-DOPA kinetics of rBAT and LAT2 showed classic Michaelis-Menton kinetics with K m s in the micromolar and millimolar range, respectively. Sequence-specific antisense oligonucleotides to rBAT or LAT2 (AS) caused inhibition of rBAT and LAT2 cRNA-induced l-DOPA transport and cortical poly-A + -induced arginine and phenylalanine transport. However, the same ASs only partially blocked poly-A + -induced l-DOPA transport. In cultured kidney cells, silencing inhibitory RNA (siRNA) to rBAT significantly inhibited l-DOPA uptake. We conclude that rBAT and LAT2 can mediate apical and basolateral l-DOPA uptake into the proximal tubule, respectively. Additional l-DOPA transport mechanisms exist in the renal cortex that remain to be identified." @default.
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• W2170372276 date "2004-07-01" @default.
• W2170372276 modified "2023-10-01" @default.
• W2170372276 title "The dopamine precursor<scp>l</scp>-dihydroxyphenylalanine is transported by the amino acid transporters rBAT and LAT2 in renal cortex" @default.
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• W2170372276 doi "https://doi.org/10.1152/ajprenal.00237.2003" @default.
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