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- W2170391371 abstract "Abstract Four pairs of virulent/avirulent strains of Legionella pneumophila were examined for their adherence/uptake and activation of human monocytes. Oxidative metabolic responses of monocytes were quantitated by measuring intracellular hydrogen peroxide generation using flow cytometry and by assessment of superoxide dismutase-inhibitable superoxide anion generation. All L pneumophila strains induced less of a response than did Escherichia coll. Within each pair of isolates, virulent strains of L. pneumophila stimulated the oxidative response of monocytes less than avirulent variants. To determine effects of complement fixation by each strain on their adherence to monocytes, a phagocytic index (PI) was determined under various conditions. In autologous donor serum (AS), all L. pneumophila strains had a PI in the range of 2.1–3.1 bacteria per monocyte, with E. coll having a PI of 9.1. No significant differences were observed between virulent L pneumophila strains and their avirulent variants. In the presence of heat-inactivated AS, all PI fell to 0.13–0.20 for the L pneumophila strains, and to 2.16 for E. coll. Using heat-inactivated AS reconstituted with exogenous human complement as a source of opsonization, levels of PI were indistinguishable from their respective levels in AS. This suggests that complement fixation plays an important role in the adherence of virulent and avirulent L pneumophila to human monocytes." @default.
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- W2170391371 date "1990-01-01" @default.
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- W2170391371 title "Interactions of Virulent and Avirulent <i>Legionella pneumophila</i> With Human Monocytes" @default.
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- W2170391371 doi "https://doi.org/10.1002/jlb.47.1.31" @default.
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