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- W2170394117 abstract "We conducted a comparative study to evaluate the quality and true nature of the fibrous tissue formed around synthetic grafts when used in ligament replacement. In one group of Lewis rats, a patellar ligament was replaced with a Dacron prosthesis; the comparison group received a tail tendon isograft. Two-, 4-, 8-, 12-, and 24-week comparisons showed histological and biochemical changes in the Dacron group alone that were consistent with foreign-body reaction. Specifically, the Dacron group showed infiltration by large numbers of macrophages and foreign-body, multinucleated giant cells. In addition, the capsule of fibrous tissue that developed around the Dacron ligaments was characterized by lower collagen solubility, a higher content of noncollagenous protein, and a higher proportion of type III collagen than that comprising the isografted tendons. The results of this study call into question the suitability of synthetics for ligament replacement." @default.
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- W2170394117 date "1992-11-01" @default.
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- W2170394117 title "Histological and biochemical analysis of the fibrous tissue induced by implantation of synthetic ligament (Dacron): An experimental study in a rat model" @default.
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- W2170394117 doi "https://doi.org/10.1002/jor.1100100618" @default.
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