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• W2170404504 endingPage "2000" @default.
• W2170404504 startingPage "1988" @default.
• W2170404504 abstract "Abstract The binding of nonspecific human IgM to the surface of infected erythrocytes is important in rosetting, a major virulence factor in the pathogenesis of severe malaria due to Plasmodium falciparum, and IgM binding has also been implicated in placental malaria. Herein we have identified the IgM-binding parasite ligand from a virulent P. falciparum strain as PfEMP1 (TM284var1 variant), and localized the region within this PfEMP1 variant that binds IgM (DBL4β domain). We have used this parasite IgM-binding protein to investigate the interaction with human IgM. Interaction studies with domain-swapped Abs, IgM mutants, and anti-IgM mAbs showed that PfEMP1 binds to the Fc portion of the human IgM H chain and requires the IgM Cμ4 domain. Polymerization of IgM was shown to be crucial for the interaction because PfEMP1 binding did not occur with mutant monomeric IgM molecules. These results with PfEMP1 protein have physiological relevance because infected erythrocytes from strain TM284 and four other IgM-binding P. falciparum strains showed analogous results to those seen with the DBL4β domain. Detailed investigation of the PfEMP1 binding site on IgM showed that some of the critical amino acids in the IgM Cμ4 domain are equivalent to those regions of IgG and IgA recognized by Fc-binding proteins from bacteria, suggesting that this region of Ig molecules may be of major functional significance in host-microbe interactions. We have therefore shown that PfEMP1 is an Fc-binding protein of malaria parasites specific for polymeric human IgM, and that it shows functional similarities with Fc-binding proteins from pathogenic bacteria." @default.
• W2170404504 created "2016-06-24" @default.
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• W2170404504 date "2008-08-01" @default.
• W2170404504 modified "2023-10-17" @default.
• W2170404504 title "Identification of Residues in the Cμ4 Domain of Polymeric IgM Essential for Interaction with<i>Plasmodium falciparum</i>Erythrocyte Membrane Protein 1 (PfEMP1)" @default.
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• W2170404504 doi "https://doi.org/10.4049/jimmunol.181.3.1988" @default.
• W2170404504 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2696179" @default.
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• W2170404504 hasPublicationYear "2008" @default.
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