FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170405736> ?p ?o ?g. }

• W2170405736 abstract "OBJECTIVE: To investigate a correlation between the elimination rate constants (K e ) of aminoglycosides (AG) and vancomycin; to investigate the correlation between actual K e and creatinine clearance (Cl cr ) for AG versus vancomycin; to investigate the calculated versus actual K e for AG and vancomycin; and to investigate a correlation between volumes of distribution (V d ) between AG and vancomycin. DESIGN: Retrospective data collection. METHODS: Patients in our institution who received AGs or vancomycin concomitantly or within six weeks of each other were identified retrospectively. Patient subpopulations were identified and analyzed collectively as well as individually. Steady-state serum concentrations of AG and vancomycin (more than four half-lives) were obtained and kinetic parameters (K e‘ V d ) were calculated using first-order pharmacokinetic equations. Linear regression was used to determine correlation coefficients. RESULTS: In the total population and all subpopulations, the correlation between K e of AG and vancomycin was superior to the correlation between K e and Cl cr . The correlations (r 2 ) between K e for AG and vancomycin in the total, general medicine, oncology, and intensive care units (ICU) populations were 0.572, 0.878, 0.349, and 0.561, respectively. The correlations (r 2 ) between K e and Cl cr for AG in the total, general medicine, oncology, and ICU populations were 0.235, 0.430, 0.005, and 0.238, respectively. The correlations (r 2 ) between K e and Cl cr for vancomycin in the total, general medicine, oncology, and ICU populations were 0.300, 0.407, 0.055, and 0.309, respectively. CONCLUSIONS: The correlation between K e of AG and vancomycin may be beneficial for predicting K e of vancomycin when AG concentrations have already been obtained or vice versa, and may give more accurate estimations of dosing intervals and require less time adjusting, ordering, and interpreting concentrations and dosages." @default.
• W2170405736 created "2016-06-24" @default.
• W2170405736 creator A5013599207 @default.
• W2170405736 creator A5060629024 @default.
• W2170405736 date "1993-11-01" @default.
• W2170405736 modified "2023-09-23" @default.
• W2170405736 title "Correlation of Aminoglycoside and Vancomycin Pharmacokinetic Parameters" @default.
• W2170405736 cites W1522872289 @default.
• W2170405736 cites W1550111394 @default.
• W2170405736 cites W1999116056 @default.
• W2170405736 cites W2000557956 @default.
• W2170405736 cites W2008160898 @default.
• W2170405736 cites W2008942121 @default.
• W2170405736 cites W2050789305 @default.
• W2170405736 cites W2068489935 @default.
• W2170405736 cites W2071521289 @default.
• W2170405736 cites W2130136798 @default.
• W2170405736 cites W2135843323 @default.
• W2170405736 cites W2163456936 @default.
• W2170405736 cites W2165282412 @default.
• W2170405736 cites W2167651673 @default.
• W2170405736 cites W2246400681 @default.
• W2170405736 doi "https://doi.org/10.1177/106002809302701107" @default.
• W2170405736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8286806" @default.
• W2170405736 hasPublicationYear "1993" @default.
• W2170405736 type Work @default.
• W2170405736 sameAs 2170405736 @default.
• W2170405736 citedByCount "4" @default.
• W2170405736 crossrefType "journal-article" @default.
• W2170405736 hasAuthorship W2170405736A5013599207 @default.
• W2170405736 hasAuthorship W2170405736A5060629024 @default.
• W2170405736 hasConcept C112705442 @default.
• W2170405736 hasConcept C117220453 @default.
• W2170405736 hasConcept C126322002 @default.
• W2170405736 hasConcept C177713679 @default.
• W2170405736 hasConcept C2524010 @default.
• W2170405736 hasConcept C2777787772 @default.
• W2170405736 hasConcept C2778980435 @default.
• W2170405736 hasConcept C2779489039 @default.
• W2170405736 hasConcept C2780306776 @default.
• W2170405736 hasConcept C2908647359 @default.
• W2170405736 hasConcept C2987404301 @default.
• W2170405736 hasConcept C33923547 @default.
• W2170405736 hasConcept C501593827 @default.
• W2170405736 hasConcept C523546767 @default.
• W2170405736 hasConcept C54355233 @default.
• W2170405736 hasConcept C71924100 @default.
• W2170405736 hasConcept C86803240 @default.
• W2170405736 hasConcept C89423630 @default.
• W2170405736 hasConcept C99454951 @default.
• W2170405736 hasConceptScore W2170405736C112705442 @default.
• W2170405736 hasConceptScore W2170405736C117220453 @default.
• W2170405736 hasConceptScore W2170405736C126322002 @default.
• W2170405736 hasConceptScore W2170405736C177713679 @default.
• W2170405736 hasConceptScore W2170405736C2524010 @default.
• W2170405736 hasConceptScore W2170405736C2777787772 @default.
• W2170405736 hasConceptScore W2170405736C2778980435 @default.
• W2170405736 hasConceptScore W2170405736C2779489039 @default.
• W2170405736 hasConceptScore W2170405736C2780306776 @default.
• W2170405736 hasConceptScore W2170405736C2908647359 @default.
• W2170405736 hasConceptScore W2170405736C2987404301 @default.
• W2170405736 hasConceptScore W2170405736C33923547 @default.
• W2170405736 hasConceptScore W2170405736C501593827 @default.
• W2170405736 hasConceptScore W2170405736C523546767 @default.
• W2170405736 hasConceptScore W2170405736C54355233 @default.
• W2170405736 hasConceptScore W2170405736C71924100 @default.
• W2170405736 hasConceptScore W2170405736C86803240 @default.
• W2170405736 hasConceptScore W2170405736C89423630 @default.
• W2170405736 hasConceptScore W2170405736C99454951 @default.
• W2170405736 hasLocation W21704057361 @default.
• W2170405736 hasLocation W21704057362 @default.
• W2170405736 hasOpenAccess W2170405736 @default.
• W2170405736 hasPrimaryLocation W21704057361 @default.
• W2170405736 hasRelatedWork W1990578792 @default.
• W2170405736 hasRelatedWork W1998612473 @default.
• W2170405736 hasRelatedWork W2005565918 @default.
• W2170405736 hasRelatedWork W2113778942 @default.
• W2170405736 hasRelatedWork W2157622955 @default.
• W2170405736 hasRelatedWork W2332402107 @default.
• W2170405736 hasRelatedWork W2406837934 @default.
• W2170405736 hasRelatedWork W2409031650 @default.
• W2170405736 hasRelatedWork W2414791649 @default.
• W2170405736 hasRelatedWork W591495101 @default.
• W2170405736 isParatext "false" @default.
• W2170405736 isRetracted "false" @default.
• W2170405736 magId "2170405736" @default.
• W2170405736 workType "article" @default.