FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170409621> ?p ?o ?g. }

• W2170409621 endingPage "2925" @default.
• W2170409621 startingPage "2917" @default.
• W2170409621 abstract "ABSTRACT The obligate intracellular bacterium Chlamydia pneumoniae is not only a causative agent of community-acquired pneumonia but is also associated with a more serious chronic disease, asthma, which might be exacerbated by air pollution containing carbon nanoparticles. Although a detailed mechanism of exacerbation remains unknown, the proinflammatory cytokine interleukin-1β (IL-1β) is a critical player in the pathogenesis of asthma. C. pneumoniae induces IL-1β in macrophages via NACHT, LRR, and PYD domain-containing protein 3 (NLRP3) inflammasome activation and Toll-like receptor 2/4 (TLR2/4) stimulation. Carbon nanoparticles, such as carbon nanotubes (CNTs), can also evoke the NLRP3 inflammasome to trigger IL-1β secretion from lipopolysaccharide-primed macrophages. This study assessed whether costimulation of C. pneumoniae with CNTs synergistically enhanced IL-1β secretion from macrophages, and determined the molecular mechanism involved. Enhanced IL-1β secretion from C. pneumoniae -infected macrophages by CNTs was dose and time dependent. Transmission electron microscopy revealed that C. pneumoniae and CNTs were engulfed concurrently by macrophages. Inhibitors of actin polymerization or caspase-1, a component of the inflammasome, significantly blocked IL-1β secretion. Gene silencing using small interfering RNA (siRNA) targeting the NLRP3 gene also abolished IL-1β secretion. Other inhibitors (K + efflux inhibitor, cathepsin B inhibitor, and reactive oxygen species-generating inhibitor) also blocked IL-1β secretion. Taken together, these findings demonstrated that CNTs synergistically enhanced IL-1β secretion from C. pneumoniae -infected macrophages via the NLRP3 inflammasome and caspase-1 activation, providing novel insight into our understanding of how C. pneumoniae infection can exacerbate asthma." @default.
• W2170409621 created "2016-06-24" @default.
• W2170409621 creator A5015070889 @default.
• W2170409621 creator A5038134703 @default.
• W2170409621 creator A5041358971 @default.
• W2170409621 creator A5043066371 @default.
• W2170409621 creator A5055429341 @default.
• W2170409621 creator A5058928994 @default.
• W2170409621 creator A5066542057 @default.
• W2170409621 creator A5084153953 @default.
• W2170409621 creator A5084403788 @default.
• W2170409621 date "2015-07-01" @default.
• W2170409621 modified "2023-09-27" @default.
• W2170409621 title "Synergistic Costimulatory Effect of Chlamydia pneumoniae with Carbon Nanoparticles on NLRP3 Inflammasome-Mediated Interleukin-1β Secretion in Macrophages" @default.
• W2170409621 cites W102714607 @default.
• W2170409621 cites W1481916388 @default.
• W2170409621 cites W1571910978 @default.
• W2170409621 cites W1577331826 @default.
• W2170409621 cites W1605844554 @default.
• W2170409621 cites W1966079664 @default.
• W2170409621 cites W1975032036 @default.
• W2170409621 cites W1978274182 @default.
• W2170409621 cites W1981013578 @default.
• W2170409621 cites W1999883189 @default.
• W2170409621 cites W2002368631 @default.
• W2170409621 cites W2018563185 @default.
• W2170409621 cites W2019959157 @default.
• W2170409621 cites W2028789055 @default.
• W2170409621 cites W2048032544 @default.
• W2170409621 cites W2051714701 @default.
• W2170409621 cites W2059969676 @default.
• W2170409621 cites W2063894714 @default.
• W2170409621 cites W2065947741 @default.
• W2170409621 cites W2073474576 @default.
• W2170409621 cites W2079234345 @default.
• W2170409621 cites W2097825875 @default.
• W2170409621 cites W2098565347 @default.
• W2170409621 cites W2098679018 @default.
• W2170409621 cites W2110373224 @default.
• W2170409621 cites W2116621726 @default.
• W2170409621 cites W2118571416 @default.
• W2170409621 cites W2118800225 @default.
• W2170409621 cites W2119776991 @default.
• W2170409621 cites W2128021591 @default.
• W2170409621 cites W2130982526 @default.
• W2170409621 cites W2139536914 @default.
• W2170409621 cites W2156128654 @default.
• W2170409621 cites W2156454461 @default.
• W2170409621 cites W2160722686 @default.
• W2170409621 cites W2165358118 @default.
• W2170409621 cites W2168398643 @default.
• W2170409621 cites W2171234056 @default.
• W2170409621 cites W2173343255 @default.
• W2170409621 cites W4255342930 @default.
• W2170409621 cites W2312504085 @default.
• W2170409621 doi "https://doi.org/10.1128/iai.02968-14" @default.
• W2170409621 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4468553" @default.
• W2170409621 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25939513" @default.
• W2170409621 hasPublicationYear "2015" @default.
• W2170409621 type Work @default.
• W2170409621 sameAs 2170409621 @default.
• W2170409621 citedByCount "12" @default.
• W2170409621 countsByYear W21704096212016 @default.
• W2170409621 countsByYear W21704096212017 @default.
• W2170409621 countsByYear W21704096212018 @default.
• W2170409621 countsByYear W21704096212019 @default.
• W2170409621 countsByYear W21704096212020 @default.
• W2170409621 crossrefType "journal-article" @default.
• W2170409621 hasAuthorship W2170409621A5015070889 @default.
• W2170409621 hasAuthorship W2170409621A5038134703 @default.
• W2170409621 hasAuthorship W2170409621A5041358971 @default.
• W2170409621 hasAuthorship W2170409621A5043066371 @default.
• W2170409621 hasAuthorship W2170409621A5055429341 @default.
• W2170409621 hasAuthorship W2170409621A5058928994 @default.
• W2170409621 hasAuthorship W2170409621A5066542057 @default.
• W2170409621 hasAuthorship W2170409621A5084153953 @default.
• W2170409621 hasAuthorship W2170409621A5084403788 @default.
• W2170409621 hasBestOaLocation W21704096211 @default.
• W2170409621 hasConcept C139964883 @default.
• W2170409621 hasConcept C164027704 @default.
• W2170409621 hasConcept C203014093 @default.
• W2170409621 hasConcept C2776088486 @default.
• W2170409621 hasConcept C2776914184 @default.
• W2170409621 hasConcept C2777038808 @default.
• W2170409621 hasConcept C2777209026 @default.
• W2170409621 hasConcept C2777391075 @default.
• W2170409621 hasConcept C2778419347 @default.
• W2170409621 hasConcept C2781253189 @default.
• W2170409621 hasConcept C49039625 @default.
• W2170409621 hasConcept C501593827 @default.
• W2170409621 hasConcept C55493867 @default.
• W2170409621 hasConcept C86803240 @default.
• W2170409621 hasConcept C89423630 @default.
• W2170409621 hasConcept C95444343 @default.
• W2170409621 hasConceptScore W2170409621C139964883 @default.
• W2170409621 hasConceptScore W2170409621C164027704 @default.
• W2170409621 hasConceptScore W2170409621C203014093 @default.
• W2170409621 hasConceptScore W2170409621C2776088486 @default.

• next