FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170413003> ?p ?o ?g. }

• W2170413003 endingPage "209" @default.
• W2170413003 startingPage "204" @default.
• W2170413003 abstract "Abstract —Vascular smooth muscle cells (VSMCs) as well as macrophages have been shown to generate a substantial amount of NO in inflammatory vascular lesions. Prostaglandin (PG) D 2 (PGD 2 ) is produced by inflammatory cells, including mast cells and macrophages. We investigated whether PGD 2 modulates NO metabolism in rat VSMCs. PGD 2 at a concentration of 10 –7 mol/L or greater dose-dependently inhibited nitrite accumulation in the medium of cultured VSMCs stimulated with interleukin 1β (IL-1β). In a dose-response analysis of IL-1β and nitrite accumulation, PGD 2 was seen to decrease the maximal ability of VSMCs to generate NO, arguing against competition by PGD 2 at cytokine receptors. Northern analysis showed that PGD 2 suppresses induction of inducible NO synthase (iNOS) mRNA in IL-1β–stimulated VSMCs, with consequent inhibition of iNOS protein expression in Western analysis. A thromboxane A 2 (TXA 2 ) analogue, U46619 (10 –5 mol/L), produced less inhibition of NO generation than did PGD 2 . Neither the PGI 2 analog carbaprostacyclin nor PGE 1 showed any inhibition. PGD 2 dose-dependently inhibited NO generation despite the addition of the TXA 2 antagonist SQ29548. PGJ 2 , Δ 12 -PGJ 2 , and 15-deoxy-Δ 12,14 -PGJ 2 , all metabolites of PGD 2 , were as potent as or slightly stronger than PGD 2 in the inhibition of NO generation. These data suggest that PGD 2 suppresses NO generation in VSMCs by inhibiting iNOS mRNA expression, most likely through the cascade of the PGJ 2 series rather than through the TX receptor or cAMP upregulation. Such action makes it likely that PGD 2 regulates NO metabolism in vascular lesions." @default.
• W2170413003 created "2016-06-24" @default.
• W2170413003 creator A5006061739 @default.
• W2170413003 creator A5006782913 @default.
• W2170413003 creator A5008934626 @default.
• W2170413003 creator A5028717780 @default.
• W2170413003 creator A5032302089 @default.
• W2170413003 creator A5034244372 @default.
• W2170413003 creator A5054807384 @default.
• W2170413003 creator A5068584955 @default.
• W2170413003 creator A5085819007 @default.
• W2170413003 creator A5089051443 @default.
• W2170413003 date "1998-02-09" @default.
• W2170413003 modified "2023-10-09" @default.
• W2170413003 title "Prostaglandin D ₂ Inhibits Inducible Nitric Oxide Synthase Expression in Rat Vascular Smooth Muscle Cells" @default.
• W2170413003 cites W1491383197 @default.
• W2170413003 cites W1522963066 @default.
• W2170413003 cites W1587534704 @default.
• W2170413003 cites W1595278449 @default.
• W2170413003 cites W1930831294 @default.
• W2170413003 cites W1981091922 @default.
• W2170413003 cites W1982937288 @default.
• W2170413003 cites W1985839335 @default.
• W2170413003 cites W1995244403 @default.
• W2170413003 cites W2005674716 @default.
• W2170413003 cites W2024352183 @default.
• W2170413003 cites W2027490559 @default.
• W2170413003 cites W2050717908 @default.
• W2170413003 cites W2054821014 @default.
• W2170413003 cites W2059769437 @default.
• W2170413003 cites W2059785252 @default.
• W2170413003 cites W2063800048 @default.
• W2170413003 cites W2064590804 @default.
• W2170413003 cites W2066270109 @default.
• W2170413003 cites W2082092019 @default.
• W2170413003 cites W2088146922 @default.
• W2170413003 cites W2094891357 @default.
• W2170413003 cites W2098693385 @default.
• W2170413003 cites W2115929723 @default.
• W2170413003 cites W2153432263 @default.
• W2170413003 cites W2216922431 @default.
• W2170413003 cites W2336035595 @default.
• W2170413003 cites W2467118200 @default.
• W2170413003 cites W70713675 @default.
• W2170413003 doi "https://doi.org/10.1161/01.res.82.2.204" @default.
• W2170413003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9468191" @default.
• W2170413003 hasPublicationYear "1998" @default.
• W2170413003 type Work @default.
• W2170413003 sameAs 2170413003 @default.
• W2170413003 citedByCount "52" @default.
• W2170413003 countsByYear W21704130032012 @default.
• W2170413003 countsByYear W21704130032013 @default.
• W2170413003 countsByYear W21704130032014 @default.
• W2170413003 countsByYear W21704130032015 @default.
• W2170413003 countsByYear W21704130032016 @default.
• W2170413003 countsByYear W21704130032018 @default.
• W2170413003 countsByYear W21704130032019 @default.
• W2170413003 countsByYear W21704130032020 @default.
• W2170413003 countsByYear W21704130032021 @default.
• W2170413003 countsByYear W21704130032022 @default.
• W2170413003 countsByYear W21704130032023 @default.
• W2170413003 crossrefType "journal-article" @default.
• W2170413003 hasAuthorship W2170413003A5006061739 @default.
• W2170413003 hasAuthorship W2170413003A5006782913 @default.
• W2170413003 hasAuthorship W2170413003A5008934626 @default.
• W2170413003 hasAuthorship W2170413003A5028717780 @default.
• W2170413003 hasAuthorship W2170413003A5032302089 @default.
• W2170413003 hasAuthorship W2170413003A5034244372 @default.
• W2170413003 hasAuthorship W2170413003A5054807384 @default.
• W2170413003 hasAuthorship W2170413003A5068584955 @default.
• W2170413003 hasAuthorship W2170413003A5085819007 @default.
• W2170413003 hasAuthorship W2170413003A5089051443 @default.
• W2170413003 hasBestOaLocation W21704130031 @default.
• W2170413003 hasConcept C126322002 @default.
• W2170413003 hasConcept C134018914 @default.
• W2170413003 hasConcept C170493617 @default.
• W2170413003 hasConcept C185592680 @default.
• W2170413003 hasConcept C2776785769 @default.
• W2170413003 hasConcept C2777361909 @default.
• W2170413003 hasConcept C2777622882 @default.
• W2170413003 hasConcept C2779395532 @default.
• W2170413003 hasConcept C2780664492 @default.
• W2170413003 hasConcept C2781024287 @default.
• W2170413003 hasConcept C2992686903 @default.
• W2170413003 hasConcept C519581460 @default.
• W2170413003 hasConcept C71924100 @default.
• W2170413003 hasConcept C86803240 @default.
• W2170413003 hasConcept C89560881 @default.
• W2170413003 hasConceptScore W2170413003C126322002 @default.
• W2170413003 hasConceptScore W2170413003C134018914 @default.
• W2170413003 hasConceptScore W2170413003C170493617 @default.
• W2170413003 hasConceptScore W2170413003C185592680 @default.
• W2170413003 hasConceptScore W2170413003C2776785769 @default.
• W2170413003 hasConceptScore W2170413003C2777361909 @default.
• W2170413003 hasConceptScore W2170413003C2777622882 @default.
• W2170413003 hasConceptScore W2170413003C2779395532 @default.
• W2170413003 hasConceptScore W2170413003C2780664492 @default.
• W2170413003 hasConceptScore W2170413003C2781024287 @default.

• next