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- W2170413306 abstract "Summary The relapsing fever agent, Borrella hermsii , undergoes multiphasic antigenic variation to evade its host's immune response. A frequently observed switch is serotype 7 to 26. Unlike silent vmp genes previously characterized, the transcriptionally silent vmp26 sequence was a pseudogene in lacking a start codon. In serotype 7 the location of the silent vmp26 sequence just downstream of vmp7 on the expression plasmid, as well as on the silent plasmid, was also unique. The demonstration of a predicted circular recombination product in serotype 7 but not serotype 21 populations indicates that the pseudogene was activated by an intramolecular recombination producing a deletion of DNA between 20‐nucleotide direct repeats in vmp7 and Ψ vmp26." @default.
- W2170413306 created "2016-06-24" @default.
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- W2170413306 date "1994-07-01" @default.
- W2170413306 modified "2023-10-11" @default.
- W2170413306 title "Activation of a<i>vmp</i>pseudogene in<i>Borrella hermsii</i>: an alternate mechanism of antigenic variation during relapsing fever" @default.
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- W2170413306 doi "https://doi.org/10.1111/j.1365-2958.1994.tb00423.x" @default.
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