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• W2170424940 abstract "Traumatic axonal injury (TAI) is thought to be a major contributor to cognitive dysfunction following traumatic brain injury (TBI), however TAI is difficult to diagnose or characterize non-invasively. Diffusion tensor imaging (DTI) has shown promise in detecting TAI, but direct comparison to histologically-confirmed axonal injury has not been performed. In the current study, mice were imaged with DTI, subjected to a moderate cortical controlled impact injury, and re-imaged 4–6 h and 24 h post-injury. Axonal injury was detected by amyloid beta precursor protein (APP) and neurofilament immunohistochemistry in pericontusional white matter tracts. The severity of axonal injury was quantified using stereological methods from APP stained histological sections. Two DTI parameters – axial diffusivity and relative anisotropy – were significantly reduced in the injured, pericontusional corpus callosum and external capsule, while no significant changes were seen with conventional MRI in these regions. The contusion was easily detectable on all MRI sequences. Significant correlations were found between changes in relative anisotropy and the density of APP stained axons across mice and across subregions spanning the spatial gradient of injury. The predictive value of DTI was tested using a region with DTI changes (hippocampal commissure) and a region without DTI changes (anterior commissure). Consistent with DTI predictions, there was histological detection of axonal injury in the hippocampal commissure and none in the anterior commissure. These results demonstrate that DTI is able to detect axonal injury, and support the hypothesis that DTI may be more sensitive than conventional imaging methods for this purpose." @default.
• W2170424940 created "2016-06-24" @default.
• W2170424940 creator A5014470968 @default.
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• W2170424940 creator A5045394358 @default.
• W2170424940 creator A5065549626 @default.
• W2170424940 creator A5088998527 @default.
• W2170424940 date "2007-05-01" @default.
• W2170424940 modified "2023-10-07" @default.
• W2170424940 title "Detection of traumatic axonal injury with diffusion tensor imaging in a mouse model of traumatic brain injury" @default.
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• W2170424940 doi "https://doi.org/10.1016/j.expneurol.2007.01.035" @default.
• W2170424940 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1995439" @default.
• W2170424940 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17368446" @default.

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